BDBM50529377 CHEMBL4558528::US11584746, Compound I-20

SMILES CN1CCN(CC1)c1ccc(Oc2ccc3Nc4ccc(F)cc4N(Cc4ccccc4)C(=O)c3c2)cc1

InChI Key InChIKey=ZPNTXOKOIHPCLI-UHFFFAOYSA-N

Data  11 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50529377   

TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged KIT V559D/V654A double mutant expressed in baculovirus expression system at 10 uM by kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of tracer 236 binding to recombinant full length human GST-tagged SLK expressed in baculovirus expression system measured after 60 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to wild-type human partial length SLK (S14 to A307 residues) expressed in bacterial expression system assessed as residual binding l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in cell growth incubated for 72 hrs in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  13nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR triple T790M/L858R/C797S mutant (696 to 1022 residues) expressed in Sf21 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  11nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR double T790M/L858R mutant (696 to 1022 residues) expressed in Sf21 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  13nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  154nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR L858R mutant (696 to 1022 residues) expressed in Sf21 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGFR triple T790M/L858R/C797S mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in cell growth incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  360nMAssay Description:Inhibition of EGFR double T790M/L858R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in cell growth incubated for 72 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse Ba/F3 cells assessed as reduction in cell growth incubated for 72 hrs in presence of 1 ug/ml C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50: <250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (696 to 1022 residues) expressed in Sf21 insect cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed