BDBM50531784 Fanotaprim::TRC-2533::TRC-2533-NX::US11530198, Example 78::VYR-006

SMILES COc1ncc(cn1)-c1cccc(c1)N1CCN(CC1)c1cnc(N)nc1N

InChI Key InChIKey=GUZBZPCNAJDYMO-UHFFFAOYSA-N

Data  8 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50531784   

TargetDihydrofolate reductase(Homo sapiens (Human))
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  308nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed by substrate and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  1.20E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  0.708nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  912nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  2.09nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  912nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  3.24nMAssay Description:TBDMore data for this Ligand-Target Pair