Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM50531784'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | VYR-006 | US...)
Affinity DataIC50: 0.708nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | VYR-006 | US...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | VYR-006 | US...)
Affinity DataIC50: 2.09nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Vyera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | VYR-006 | US...)
Affinity DataIC50: 3.24nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent