BDBM50532743 CHEMBL4527749

SMILES CCN1CCC(CCNC(=O)Nc2nc3ccc(Sc4nnc5ccc(nn45)-c4cccs4)cc3s2)CC1

InChI Key InChIKey=TYRAWDXLPFZNOP-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50532743   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  29nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  29nMAssay Description:Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  23nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  23nMAssay Description:Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532743(CHEMBL4527749)
Affinity DataIC50:  2nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB