BDBM50549221 CHEMBL4293433

SMILES Oc1cc(Cl)c(I)cc1NCC(=O)N1CCN(CC1)C(=O)C=C

InChI Key InChIKey=JFIFBWVNHLXJFY-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549221   

TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50549221(CHEMBL4293433)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells incubated for 6 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50549221(CHEMBL4293433)
Affinity DataEC50:  320nMAssay Description:Inhibition of KRas G12C mutant in human NCI-H1792 cells assessed as antiproliferative activity incubated for 3 days by CellTiter-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed