BDBM50560790 CHEMBL4741283
SMILES Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@@H]4O)sc3c2)c1Cl
InChI Key InChIKey=NGKALCMOLVCFHL-ZFWWWQNUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50560790
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 1.10nMAssay Description:Binding affinity to human wild type CSF1R (I564 to S939 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 65nMAssay Description:Binding affinity to human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 0.840nMAssay Description:Binding affinity to human wild type PDGFRbeta (V582 to Y1009 residues) expressed in bacterial expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 1.30nMAssay Description:Binding affinity to human wild type PDGFRalpha (V575 to D1002 residues) expressed in mammalian expression system by kinome scan assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
University Of Texas Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataKd: 44nMAssay Description:Binding affinity to c-Kit (unknown origin) by kinome scan assayMore data for this Ligand-Target Pair