BDBM50591035 CHEMBL5187422

SMILES Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1

InChI Key InChIKey=LHFFKHVGAKIDNO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50591035   

TargetDNA polymerase theta(Homo sapiens)
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Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of N-terminal His8-tagged/C-terminal FLAG-tagged full length human DNA polymerase theta ( 1 to 2590 residues) polymerase activity expresse...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  940nMAssay Description:Inhibition of DNA polymerase theta in LIG4 knock out HEK293T cells assessed as decrease in MMEJ-mediated DNA repair preincubated for 1 day followed b...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase nu(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase nuMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails PubMed