BDBM534351 WO2018148626, Example 78::WO2022086828, Example 78
SMILES Nc1nc2cc(ccn2n1)-c1ccc(Cl)c(C(=O)NCCC(O)c2ccc(F)cc2)c1F
InChI Key InChIKey=HKDBKENBVSIISE-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 534351
Affinity DataIC50: 19nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb
WIPO
Bristol-Myers Squibb
WIPO
Affinity DataIC50: 9.90nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb
WIPO
Bristol-Myers Squibb
WIPO
Affinity DataIC50: 120nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb
WIPO
Bristol-Myers Squibb
WIPO
Affinity DataIC50: 19nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair