BDBM616694 US20230278998, Comparative Compound 1'::US20230303556, Example 38 from WO2021/055744
SMILES CC(C)C(=O)N1CCN(CC1)c1cc(cc2n(ncc12)-c1nnc(s1)C(F)F)S(=O)(=O)NC1(CC1)C#N
InChI Key InChIKey=PTPOIRINZRNCAE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 616694
Affinity DataIC50: 1.90nMAssay Description:PARG in vitro assays were conducted in standard 384-well plates in a total volume of 15 μL. 5 μL of PARG (389-976) (manufactured by Chempar...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair