BDBM616694 US20230278998, Comparative Compound 1'::US20230303556, Example 38 from WO2021/055744

SMILES CC(C)C(=O)N1CCN(CC1)c1cc(cc2n(ncc12)-c1nnc(s1)C(F)F)S(=O)(=O)NC1(CC1)C#N

InChI Key InChIKey=PTPOIRINZRNCAE-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 616694   

TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
280 Bio

US Patent
LigandPNGBDBM616694(US20230278998, Comparative Compound 1' | US2023030...)
Affinity DataIC50:  1.90nMAssay Description:PARG in vitro assays were conducted in standard 384-well plates in a total volume of 15 μL. 5 μL of PARG (389-976) (manufactured by Chempar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly(ADP-ribose) glycohydrolase(Homo sapiens (Human))
280 Bio

US Patent
LigandPNGBDBM616694(US20230278998, Comparative Compound 1' | US2023030...)
Affinity DataEC50:  19nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent