BDBM621073 Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methylpyridin-2-yl)-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyridine-3-carboxamide ::US20230303562, Example 11

SMILES Cc1cccc(n1)-n1nccc1-c1ccc2ncc(C(N)=O)n2c1

InChI Key InChIKey=HULQVTAEMIYULR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 621073   

TargetActivin receptor type-1(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50:  0.5nMAssay Description:(Promega), the inhibitory effect of the compounds of the present invention on the enzymatic activity of TGFβR1 was determined, and the steps wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50:  593nMAssay Description:Experimental method: According to the instructions of ADP-Glo Kinase Detection Kit (Promega), the inhibitory effect of the compounds of the present i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:3.2. Inhibition of CYP2D6: Test group: The test compound of different concentration was added to the microplate, and Luciferin-ME EGE (3 μM), K3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:3.2. Inhibition of CYP2D6: Test group: The test compound of different concentration was added to the microplate, and Luciferin-ME EGE (3 μM), K3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:3.2. Inhibition of CYP2D6: Test group: The test compound of different concentration was added to the microplate, and Luciferin-ME EGE (3 μM), K3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sichuan Kelun-Biotech Biopharmaceutical

US Patent
LigandPNGBDBM621073(Synthesis of 5-(3-(4-fluorobenzylamino)-1-(6-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:1. Test System: Kit: Predictor hERG fluorescence polarization detection kit (ThermoFisher), the kit contained the following components: positive cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent