BDBM627228 3-[3-(difluoromethoxy)phenyl]- N-(3-methyl-1,1-dioxo-thietan-3- yl)-1-sec-butyl-pyrazolo[4,3- b]pyridine-6-carboxamide (slower eluting in AD-H column, 20% MeOH/CO2)::US11787810, Example 66b::US20240059700, Example 66b

SMILES CC[C@H](C)n1nc(-c2cccc(OC(F)F)c2)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1

InChI Key InChIKey=QZLSVGCRYDNHFG-ZDUSSCGKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 627228   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627228(3-[3-(difluoromethoxy)phenyl]- N-(3-methyl-1,1-dio...)
Affinity DataIC50:  1.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM627228(3-[3-(difluoromethoxy)phenyl]- N-(3-methyl-1,1-dio...)
Affinity DataIC50:  1.5nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent