BDBM648812 8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]octan-6-yl)-6-methyl-N-(1-((1- methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4- yl)pyrido[3,4-d]pyrimidin-2-amine::US20240034731, Compound 11::US20240034731, Compound 97
SMILES CN1CC2(C1)CN(CC2(F)F)c1nc(C)cc2cnc(NC3CCN(CC3)S(=O)(=O)c3cnn(C)c3)nc12
InChI Key InChIKey=PSPYSXVDAKRCEF-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 648812
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: <200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar
Ligand Info
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Iambic Therapeutics
US Patent
Iambic Therapeutics
US Patent
Affinity DataIC50: <200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: <200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
Ligand Info