BDBM648812 8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]octan-6-yl)-6-methyl-N-(1-((1- methyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4- yl)pyrido[3,4-d]pyrimidin-2-amine::US20240034731, Compound 11::US20240034731, Compound 97

SMILES CN1CC2(C1)CN(CC2(F)F)c1nc(C)cc2cnc(NC3CCN(CC3)S(=O)(=O)c3cnn(C)c3)nc12

InChI Key InChIKey=PSPYSXVDAKRCEF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 648812   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Iambic Therapeutics

US Patent
LigandPNGBDBM648812(8-(8,8-difluoro-2-(methyl-d3)-2,6- diazaspiro[3.4]...)
Affinity DataIC50: <200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent