BDBM7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3

SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1

InChI Key InChIKey=IQPNAANSBPBGFQ-UHFFFAOYSA-N

Data  26 KI  125 IC50  2 Kd  13 EC50  1 ITC

PDB links: 15 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 7459   

TargetTransthyretin(Homo sapiens (Human))
Ume£

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKd:  70nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
TargetProtein polybromo-1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKd:  1.29E+4nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 7459   

CellTranscriptional Regulator TtgR(Pseudomonas putida)
Estacion Experimental Del Zaidin

SyringePNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
ITC DataΔG°: -7.12kcal/mole −TΔS°: -4.08kcal/mole ΔH°: -3.05kcal/mole logk: 1.38E+5
pH: 7.0 T: 30.00°C