BDBM9463 3-(1H-Imidazol-1-ylmethyl)-5H-indeno[1,2-c]pyridazin-5-one::CHEMBL387518::Indenodiazine deriv. 10

SMILES O=C1c2ccccc2-c2nnc(Cn3ccnc3)cc12

InChI Key InChIKey=GFPNFJWMHLRZIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9463   

TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9463(3-(1H-Imidazol-1-ylmethyl)-5H-indeno[1,2-c]pyridaz...)
Affinity DataIC50:  2.66E+4nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9463(3-(1H-Imidazol-1-ylmethyl)-5H-indeno[1,2-c]pyridaz...)
Affinity DataIC50:  2.66E+4nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9463(3-(1H-Imidazol-1-ylmethyl)-5H-indeno[1,2-c]pyridaz...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed