BDBM9471 4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-one::CHEMBL225472::Coumarin deriv. 20

SMILES COc1ccc2c(Cn3ccnc3)cc(=O)oc2c1

InChI Key InChIKey=RXGZIFUPFPVCQO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 9471   

TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataIC50:  280nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9471(4-(1H-Imidazol-1-ylmethyl)-7-methoxy-2H-chromen-2-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed