BDBM9472 7-Methoxy-4-(1H-1,2,4-triazol-1-ylmethyl)-2H-chromen-2-one::CHEMBL388604::Coumarin deriv. 21

SMILES COc1ccc2c(Cn3cncn3)cc(=O)oc2c1

InChI Key InChIKey=LWFOLZPZYGVKAO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9472   

TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9472(7-Methoxy-4-(1H-1,2,4-triazol-1-ylmethyl)-2H-chrom...)
Affinity DataIC50:  3.60E+3nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9472(7-Methoxy-4-(1H-1,2,4-triazol-1-ylmethyl)-2H-chrom...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Bari

LigandPNGBDBM9472(7-Methoxy-4-(1H-1,2,4-triazol-1-ylmethyl)-2H-chrom...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed