BDBM9475 4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-one::CHEMBL437731::Coumarin deriv. 24

SMILES O=c1cc(Cn2ccnc2)c2ccc(Oc3ccccc3)cc2o1

InChI Key InChIKey=FUYHNARLSZKQAR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 9475   

TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  51nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human placental microsomal CYP19 using [1beta-3H]androstenedione substrate pre-incubated for 5 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  933nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh11B1 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human placental aromatase in presence of [1beta,2beta-3H] testosterone by Thompson and Siiteri methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of Bari

LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human placental microsomal aromatase using testosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM9475(4-(1H-Imidazol-1-ylmethyl)-7-phenoxy-2H-chromen-2-...)
Affinity DataIC50:  2.19E+3nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh11B2 cells using [1,2-3H]-11-deoxycorticosterone substrate incubated for 25 mins by HPLC metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed