Compile Data Set for Download or QSAR
Report error Found 355 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1E'
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  4nMAssay Description:Binding affinity was determined against 5-hydroxytryptamine 1E receptor in human cortical homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  6.16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50091438BDBM50091438((E)-3-(3,4-dichlorophenyl)-N-(5-(4-(5-hydroxy-1H-i...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for 5-hydroxytryptamine 1E receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Rat)
The Scripps Research Institute

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  7.24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50456743BDBM50456743(CHEMBL4217810)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50456726BDBM50456726(CHEMBL4218231)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50456745BDBM50456745(CHEMBL4207302)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  11.0nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 10755BDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 84994BDBM84994(NSC_163091 | CAS_163091 | ORG-5222)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50016479BDBM50016479(CHEMBL160976 | LYSERGOL | CHEMBL39947 | cid_14987 ...)
Affinity DataKi:  42.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50016479BDBM50016479(CHEMBL160976 | LYSERGOL | CHEMBL39947 | cid_14987 ...)
Affinity DataKi:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  44nMAssay Description:The binding affinities shown in table 5 of psilocin and compound 8 at various monoaminergic receptors were determined in radioligand competition bind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50081701BDBM50081701(4-hydroxy-N,N-dimethyltryptamine | N,N-dimethyl-4-...)
Affinity DataKi:  44.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50056445BDBM50056445(lisuride, (S) | lisuride | N'-((8alpha)-9,10-Dideh...)
Affinity DataKi:  44.3nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50031942BDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  59nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81446BDBM81446(CAS_60-79-7 | NSC_104873 | ERGONOVINE)
Affinity DataKi:  87.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81446BDBM81446(CAS_60-79-7 | NSC_104873 | ERGONOVINE)
Affinity DataKi:  88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50330860BDBM50330860(Methylergometrine | CHEMBL1201356 | METHYLERGONOVI...)
Affinity DataKi:  89nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50330860BDBM50330860(Methylergometrine | CHEMBL1201356 | METHYLERGONOVI...)
Affinity DataKi:  89.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50241702BDBM50241702([N-methyl-3H]LSD | CHEMBL463207 | lsd)
Affinity DataKi:  92.9nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 21342BDBM21342((4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[...)
Affinity DataKi:  93nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50240412BDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 99nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1E receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50240412BDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 99nMAssay Description:Binding affinity to 5HT1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50449038BDBM50449038(CHEMBL3126204 | US9212144, 15 (Ex. 17))
Affinity DataKi: <100nMAssay Description:Displacement of [3H]5-HT from human 5-HT1E receptor expressed in HEK cells after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50052339BDBM50052339(2-(8-Bromo-2,3,6,7-tetrahydro-benzo[1,2-b;4,5-b']d...)
Affinity DataKi:  110nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50005267BDBM50005267(CHEMBL292821 | 2-(4-Bromo-2,5-dimethoxy-phenyl)-et...)
Affinity DataKi:  120nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81781BDBM81781(5-HT,omega-N-Me | 5-HT,a-Me)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 78940BDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 81781BDBM81781(5-HT,omega-N-Me | 5-HT,a-Me)
Affinity DataKi:  121nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 707625BDBM707625(rr-2b)
Affinity DataKi:  138nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50118577BDBM50118577((2,4-Dimethyl-azetidin-1-yl)-(7-methyl-4,6,6a,7,8,...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50027065BDBM50027065(12'-hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergota...)
Affinity DataKi:  155nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50582603BDBM50582603(CHEMBL5091373)
Affinity DataKi:  180nMAssay Description:Binding affinity to 5-HT1ER (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 78940BDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  194nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 707624BDBM707624(cis-2a)
Affinity DataKi:  195nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 78940BDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  195nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50118576BDBM50118576((2,4-Dimethyl-azetidin-1-yl)-(7-methyl-4,6,6a,7,8,...)
Affinity DataKi:  200nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Rat)
The Scripps Research Institute

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 78940BDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 78940BDBM78940(methanesulfonic acid;1-methyl-4-(3-methylsulfanyl-...)
Affinity DataKi:  209nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50007407BDBM50007407(CHEMBL277120 | 1-NP | 1-Naphthalen-1-yl-piperazine...)
Affinity DataKi:  209nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50031942BDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  219nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50031942BDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  228nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50031942BDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  229nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 707626BDBM707626(ss-2c)
Affinity DataKi:  276nMAssay Description:Table S2 shows raw Ki data for the current study combined with data collected from the literature for the ten additional compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/24/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50118579BDBM50118579((2,4-Dimethyl-azetidin-1-yl)-(7-methyl-4,6,6a,7,8,...)
Affinity DataKi:  280nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Rat)
The Scripps Research Institute

Curated by PDSP Ki Database
LigandChemical structure of BindingDB Monomer ID 50031942BDBM50031942(CHEMBL1065 | Sansert | (6aR,9R)-4-Methyl-4,6,6a,7,...)
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details Article
PubMed
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