Compile Data Set for Download or QSAR
Report error Found 265 Enz. Inhib. hit(s) with Target = 'A disintegrin and metalloproteinase with thrombospondin motifs 6'
LigandPNGBDBM429751(US10550100, Compound 72 | 5-(3-(4-(4- fluoro-3,5- ...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471740((R)-5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) pip...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429750(US10550100, Compound 71 | 5-(3-(4-(4,5- dichloro-2...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471743(5-cyclopropyl-5- [3-[(3S)-4-(3,4- difluoro-5- meth...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471736(5-cyclopropyl-5- [3-[4-(3,4- difluoro-5- methoxy- ...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429752(US10550100, Compound 73 | 5-(3-(4-(3- chloro-4- fl...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429747(US10550100, Compound 68 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429748(US10550100, Compound 69 | (R)-5-(3-(4- (3,4-dichlo...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429745(US10550100, Compound 66 | (R)-5-(3-(4-(3- chloro-5...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429741(US10550100, Compound 62 | 5-(3-(4-(4,5- dichloro-2...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429740(US10550100, Compound 61 | (R)-5-(3-(4- (4,5-dichlo...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429768(US10550100, Compound 88 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429767(US10550100, Compound 87 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471788((5S)-5- cyclopropyl- 5-[3-[(3S)-4-(3,4- difluoro-5...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429770(US10550100, Compound 90 | (5R)-5-[3-[4- [4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429769(US10550100, Compound 89 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429763(US10550100, Compound 84 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471771(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429765(US10550100, Compound 85 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471775(5-[3-[4-(4-chloro- 3,5-dimethoxy- phenyl) piperazi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429759(US10550100, Compound 80 | (5R)-5-[3-[4- (3-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429758(US10550100, Compound 79 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471769(5-cyclopropyl-5- [(2S)-3-[(3S)-4- (3,4-difluoro-5-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429761(US10550100, Compound 82 | (5R)-5-[3-[4- (4-fluoro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471764((5S)-5- cyclopropyl- 5-[(2S)-3-[4-(3- fluoro-5-met...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429760(US10550100, Compound 81 | (5R)-5-[3-[4- (4-fluoro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471766((5R)-5-[(2S)-3-[4- (3-fluoro-5- methoxy- phenyl) p...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471761(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471757(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429780(US10550100, Compound 104 | 5-[3-[4-(4- chloro-3-et...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471801(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429779(US10550100, Compound 103 | 5-[3-[4-(4- chloro-3- f...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471827(5-[3-[(3S)-4-(3- chloro-4-fluoro-5- methoxy-phenyl...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429782(US10550100, Compound 106 | (5R)-5-[3-[4- (4-chloro...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471799(5-[3-[4-(3-chloro- 4-fluoro-5- methoxy- phenyl) pi...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429781(US10550100, Compound 105 | (5R)-5-[3-[4- (4-chloro...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471800(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429776(US10550100, Compound 100 | (5R)-5-[3-[4- (4-chloro...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471797(5-[3-[4-(3,4- dichloro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471798(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429778(US10550100, Compound 102 | 5-[3-[4-(4- chloro-3- f...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471795(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM471796(5-[3-[(3S)-4-(4- chloro-3-methoxy- phenyl)-3-methy...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429772(US10550100, Compound 96 | (5R)-5-[3-[4- (4,5-dichl...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471933(5-[3-[(3S)-4-(4- chloro-3,5- dimethoxy- phenyl)- 3...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429797(US10550100, Compound 95 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM429774(US10550100, Compound 98 | (5R)-5-[3-[4- (4-chloro-...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471793(5-[3-[(3S)-4-(3,4- difluoro-5- methoxy-phenyl)- 3-...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

LigandPNGBDBM429773(US10550100, Compound 97 | 5-[3-[4-(4- chloro-2- me...)
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent

LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: 12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

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