Compile Data Set for Download or QSAR
Report error Found 343 Enz. Inhib. hit(s) with Target = 'Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor'
LigandChemical structure of BindingDB Monomer ID 50213212BDBM50213212(CHEMBL50390)
Affinity DataKi:  0.25nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50562355BDBM50562355(CHEMBL4755913)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50019492BDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50019492BDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  0.912nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50052882BDBM50052882(AGN-193080 | Imidazolidin-2-ylidene-(5-methyl-3,4-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50052880BDBM50052880(Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50052880BDBM50052880(Imidazolidin-2-ylidene-(5-methyl-quinoxalin-6-yl)-...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50019492BDBM50019492(RX821002 | CHEMBL10332 | 2-(2-methoxy-2,3-dihydrob...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]RX821002 from alpha-2 adrenergic receptor in human brain pre-frontal cortex neural membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 34572BDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to alpha2 adrenoceptor in human cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50021809BDBM50021809((2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-yliden...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476638BDBM50476638(CHEMBL75389)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476638BDBM50476638(CHEMBL75389)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50562354BDBM50562354(CHEMBL4763113)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 34572BDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor of HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 34572BDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details
PDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 34572BDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50213214BDBM50213214(CHEMBL42139)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50016897BDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50021812BDBM50021812(2,6-Dichloro-N-imidazolidin-2-ylidene-benzene-1,4-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50019848BDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in post-mortem human brain frontal cortex membrane measured after 30 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50029050BDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 31046BDBM31046(SMR000059054 | cid_91430 | 3-[4,5-dihydro-1H-imida...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50213211BDBM50213211(CHEMBL50769)
Affinity DataKi:  5.20nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50213028BDBM50213028(CHEMBL74283)
Affinity DataKi:  6nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50225305BDBM50225305(CHEMBL433730)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50052881BDBM50052881(Imidazolidin-2-ylidene-(5-methyl-1,2,3,4-tetrahydr...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor in HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50225327BDBM50225327(CHEMBL31062)
Affinity DataKi:  7nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50001885BDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity towards human alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50213213BDBM50213213(CHEMBL50430)
Affinity DataKi:  7.80nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50029050BDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50013515BDBM50013515(yohimbic acid methyl ester | 17alpha-hydroxyyohimb...)
Affinity DataIC50: 8nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50019057BDBM50019057((+/-)4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-be...)
Affinity DataKi:  9nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50052881BDBM50052881(Imidazolidin-2-ylidene-(5-methyl-1,2,3,4-tetrahydr...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50225302BDBM50225302(CHEMBL433083)
Affinity DataKi:  11nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50562353BDBM50562353(CHEMBL3216452)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50019061BDBM50019061(CHEMBL281232 | 4-(2-Amino-1-hydroxy-ethyl)-5-fluor...)
Affinity DataKi:  12nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225343BDBM50225343(CHEMBL31195)
Affinity DataKi:  15nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 66983BDBM66983(MLS002172470 | SMR001254100 | SKF-86466 hydrochlor...)
Affinity DataKi:  17nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50476634BDBM50476634(CHEMBL244987 | 4,4''-Di(2-Imidazolidinylimino)Diph...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225303BDBM50225303(CHEMBL52069)
Affinity DataKi:  18nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225285BDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225285BDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225285BDBM50225285(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from adrenergic alpha2 receptor in human brain frontal cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50225334BDBM50225334(CHEMBL281064)
Affinity DataKi:  25nMAssay Description:Binding affinity towards alpha 2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2018
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50029051BDBM50029051(4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol | ...)
Affinity DataKi:  30nMAssay Description:Binding affinity against alpha 2-Adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]clonidineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50270852BDBM50270852(CHEMBL4125770)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenergic receptor in human brain prefrontal cortex membranes after 30 mins by microbeta liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50562356BDBM50562356(CHEMBL4798553)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-RX821002 from adrenergic alpha 2 receptor in human brain membrane by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50213216BDBM50213216(CHEMBL883)
Affinity DataKi:  41nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50213029BDBM50213029(CHEMBL49395)
Affinity DataKi:  41nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details

LigandChemical structure of BindingDB Monomer ID 50479675BDBM50479675(CHEMBL473567)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]RX821002 from alpha2 adrenoceptor in human prefrontal cortex neural membrane after 30 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
Displayed 1 to 50 (of 343 total ) | Next | Last >>
Jump to: