Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with Target = 'Cyclin-A2 [177-432]/Cyclin-dependent kinase 2'
LigandChemical structure of BindingDB Monomer ID 35167BDBM35167(indazole-benzimidazole, 3)
Affinity DataIC50: 4.10nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35190BDBM35190(pyrazolo[3,4-b]-pyridine, 2)
Affinity DataIC50: 5nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 533739BDBM533739(US11225492, Compound 7)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533740BDBM533740(US11225492, Compound 7R)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533726BDBM533726(US11225492, Compound 3 | 2-(5-(2,7-Diazaspiro[3.5]...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533751BDBM533751(US11225492, Compound 14 | Preparation of 7-(4-(6-(...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533754BDBM533754(US11225492, Compound 15 | Preparation of 8-(4-(6-(...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533755BDBM533755(US11225492, Compound 16 | Preparation of 4-((4-(6-...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533741BDBM533741(US11225492, Compound 7S)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533742BDBM533742(US11225492, Compound 8 | Preparation of 6-acetyl-8...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533737BDBM533737(US11225492, Compound 5 | Preparation of 2-(5-(3,9-...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533738BDBM533738(US11225492, Compound 6)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533586BDBM533586(US11225492, Compound 1 | 2-(5-(3,7-diazabicyclo[3....)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533749BDBM533749(US11225492, Compound 12 | Preparation of 8-(4-(6-(...)
Affinity DataIC50: 10nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 35168BDBM35168(indazole-benzimidazole, 4)
Affinity DataIC50: 13.3nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 533727BDBM533727(US11225492, Compound 4-1)
Affinity DataIC50: 25nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533621BDBM533621(US11225492, Compound 2 | 2-(5-(9-oxa-3,7-diazabicy...)
Affinity DataIC50: 25nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533750BDBM533750(US11225492, Compound 13 | Preparation of 5-(4-(6-(...)
Affinity DataIC50: 25nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50110183BDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 39nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 515951BDBM515951(US11053238, Com. EX. 5)
Affinity DataIC50: 40nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 515983BDBM515983(US11053238, Com. EX. 6)
Affinity DataIC50: 40nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533728BDBM533728(US11225492, Compound 4-2)
Affinity DataIC50: 50nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533757BDBM533757(US11225492, Compound 17 | Preparation of 6-((6-ace...)
Affinity DataIC50: 50nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 533760BDBM533760(US11225492, Compound 18 | Preparation of 6-((6-ace...)
Affinity DataIC50: 50nMAssay Description:In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitors phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 35166BDBM35166(indazole-benzimidazole, 1)
Affinity DataIC50: 102nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35176BDBM35176(indazole-benzimidazole, 12)
Affinity DataIC50: 247nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 515923BDBM515923(US11053238, Compound 16b | US11053238, Example 16b)
Affinity DataIC50: 300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 515904BDBM515904(4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5...)
Affinity DataIC50: 300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 515905BDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50: 300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 35173BDBM35173(indazole-benzimidazole, 9)
Affinity DataIC50: 1.04E+3nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 172196BDBM172196(US9096594, 22 | US9090564, 10)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 35175BDBM35175(indazole-benzimidazole, 11)
Affinity DataIC50: 1.73E+3nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 172197BDBM172197(US9096594, 54 | US9090564, 11)
Affinity DataIC50: 3.90E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 35174BDBM35174(indazole-benzimidazole, 10)
Affinity DataIC50: 6.10E+3nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35171BDBM35171(indazole-benzimidazole, 7)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35172BDBM35172(indazole-benzimidazole, 8)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35177BDBM35177(indazole-benzimidazole, 13)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35178BDBM35178(indazole-benzimidazole, 14)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35181BDBM35181(indazole-benzimidazole, 17)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35182BDBM35182(indazole-benzimidazole, 18)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35183BDBM35183(indazole-benzimidazole, 19)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35186BDBM35186(indazole-benzimidazole, 22)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35187BDBM35187(indazole-benzimidazole, 23)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35170BDBM35170(indazole-benzimidazole, 6)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35169BDBM35169(indazole-benzimidazole, 5)
Affinity DataIC50: 2.15E+4nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 35179BDBM35179(indazole-benzimidazole, 15)
Affinity DataIC50: 1.09E+5nMT: 2°CAssay Description:Protein kinase C (PKC), zeta activity was measured by following the phosphorylation of a biotinylated peptide substrate in the presence of ATP using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed