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Found 187 Enz. Inhib. hit(s) with Target = 'Gastric inhibitory polypeptide'
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360598(CHEMBL1933364)
Affinity DataKi:  300nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360598(CHEMBL1933364)
Affinity DataKi:  300nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360599(CHEMBL1933365)
Affinity DataKi:  927nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360599(CHEMBL1933365)
Affinity DataKi:  927nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360597(CHEMBL1933363)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360594(CHEMBL1933360)
Affinity DataKi:  4.08E+3nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360594(CHEMBL1933360)
Affinity DataKi:  4.08E+3nMAssay Description:Displacement of [125I]GIP from human GIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245060((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)
Affinity DataIC50:  12nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  28nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202060(3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxy...)
Affinity DataIC50:  38nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50171817(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Affinity DataIC50:  42nMAssay Description:Binding affinity to GIPR in rat liver membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334486(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50566470(CHEMBL4857523)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202031(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Affinity DataIC50:  64nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245062((R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylph...)
Affinity DataIC50:  74nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245099((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-t...)
Affinity DataIC50:  83nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244457((R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)
Affinity DataIC50:  87nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245098((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichloroph...)
Affinity DataIC50:  93nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202041(CHEMBL375167 | trans-3-{4-[3-(3,5-Bis(trifluoromet...)
Affinity DataIC50:  93nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245057((R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-m...)
Affinity DataIC50:  98nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199497(1-(7-((2H-tetrazol-5-yl)carbamoyl)-3,4-dihydro-2H-...)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199493(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(triflu...)
Affinity DataIC50:  118nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Mus musculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50566470(CHEMBL4857523)
Affinity DataIC50:  125nMAssay Description:Antagonist activity at mouse GIPR expressed in CHO-K1 cells assessed as inhibition of GIP-induced cAMP productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199498(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Affinity DataIC50:  132nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244509((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-tr...)
Affinity DataIC50:  145nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199488(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Affinity DataIC50:  171nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199491(1-(6-((2H-tetrazol-5-yl)carbamoyl)-1,2,3,4-tetrahy...)
Affinity DataIC50:  178nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245061((R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4...)
Affinity DataIC50:  198nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29106(aminothiazole, 3)
Affinity DataIC50:  207nMAssay Description:Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244506((R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)...)
Affinity DataIC50:  216nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50202031(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Affinity DataIC50:  216nMAssay Description:Binding affinity to GIPR in rat liver membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199489(3-(4-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Affinity DataIC50:  217nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244505((R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-...)
Affinity DataIC50:  220nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245100((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-...)
Affinity DataIC50:  277nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244508((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy...)
Affinity DataIC50:  279nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199486(3-(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(tri...)
Affinity DataIC50:  286nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50358373(CHEMBL1922839)
Affinity DataIC50:  290nMAssay Description:Inhibition of human GIP receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50199492(1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-...)
Affinity DataIC50:  296nMAssay Description:Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50393781(CHEMBL2159337)
Affinity DataIC50:  307nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245056((R/S)-3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluorom...)
Affinity DataIC50:  315nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29132(thiazole, 29)
Affinity DataIC50:  316nMAssay Description:Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244455((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)
Affinity DataIC50:  359nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29107(aminothiazole, 4)
Affinity DataIC50:  368nMAssay Description:Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50358368(CHEMBL1922834)
Affinity DataIC50:  370nMAssay Description:Inhibition of human GIP receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244458((S)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)
Affinity DataIC50:  373nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50393783(CHEMBL2159339)
Affinity DataIC50:  378nMAssay Description:Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50244507((R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4...)
Affinity DataIC50:  380nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29130(thiazole, 27)
Affinity DataIC50:  381nMAssay Description:Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29104(aminothiazole, 1)
Affinity DataIC50:  389nMAssay Description:Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50245059((R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylp...)
Affinity DataIC50:  406nMAssay Description:Binding affinity to human cloned GIPR expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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