Compile Data Set for Download or QSAR
Report error Found 3666 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1'
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 707642BDBM707642(US12167998, Compound 25-FNL-27)
Affinity DataEC50:  0.000349nMAssay Description:Assays were conducted as described in Moskal et al. (Moskal, J. R., Kuo, A. G., Weiss, C., Wood, P. L., O'Connor Hanson, A., Kelso, S., Harris, R...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/28/2025
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451503BDBM50451503(CHEMBL12513)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474799BDBM50474799(CHEMBL416690)
Affinity DataKi:  0.400nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451786BDBM50451786(CHEMBL423244)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451785BDBM50451785(CHEMBL159675)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474791BDBM50474791(CHEMBL65693)
Affinity DataKi:  0.680nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50124885BDBM50124885(N-(2-methoxybenzyl)cinnamamidine | (E)-N-(2-Methox...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451505BDBM50451505(CHEMBL274422)
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474791BDBM50474791(CHEMBL65693)
Affinity DataIC50: 0.720nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451789BDBM50451789(CHEMBL159762)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474809BDBM50474809(CHEMBL65454)
Affinity DataKi:  0.820nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474789BDBM50474789(CHEMBL68134)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50062599BDBM50062599(CHEMBL807 | Namenda | 3,5-Dimethyl-adamantan-1-yla...)
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50123790BDBM50123790(3-{[4-Aminomethyl-2-(1-carboxy-ethyl)-phenylcarbam...)
Affinity DataKi:  1nMAssay Description:Binding affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of [3H]- DCKA (5,7-dichlorokynurenic acid) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215294BDBM50215294(2-(N-(6-chloro-7-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50073956BDBM50073956({5-Aminomethyl-2-[2-(9-chloro-2,3-dioxo-2,3,6,7-te...)
Affinity DataIC50: 1nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50038168BDBM50038168(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451766BDBM50451766(CHEMBL159761)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451505BDBM50451505(CHEMBL274422)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474796BDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474796BDBM50474796(CHEMBL64941)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451778BDBM50451778(CHEMBL159416)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50471539BDBM50471539(CHEMBL117627)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human NR1a/NR2B receptor expressed in mouse fibroblast LMTK cells assessed as inhibition of Glu/Gly induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50284800BDBM50284800(((5R,6S)-9-Bromo-6-ethyl-2,3-dioxo-2,3,6,7-tetrahy...)
Affinity DataKi:  1.40nMAssay Description:Affinity measured by using [3H]5,7-dichlorokynurenic acid (DCKA) for the glycine binding site of NMDA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451772BDBM50451772(CHEMBL159453)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451769BDBM50451769(CHEMBL159902)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50038171BDBM50038171(7-Chloro-4-hydroxy-3-[3-(thiophen-3-yloxy)-phenyl]...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of the binding of [3H]L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50123792BDBM50123792(3-[(4-Aminomethyl-2-carboxymethyl-phenylcarbamoyl)...)
Affinity DataIC50: 1.5nMAssay Description:Affinity for glycine site of N-methyl-D-aspartate glutamate receptor determined by displacement of tritium labeled selective glycine antagonist [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143890BDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H](E)-N1-(2-methoxybenzyl)cinnamamidine from human NR1a/NR2b receptor expressed in mouse Ltk cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50143890BDBM50143890(2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimidazol...)
Affinity DataKi:  1.5nMAssay Description:Compound was evaluated for in vitro inhibition of [3H][(E)-N-(2-methoxybenzyl)cinnamamidine binding to human NR1a/NR2B receptors expressed in LtK-cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451784BDBM50451784(CHEMBL159790)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50471520BDBM50471520(CHEMBL117691)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451779BDBM50451779(CHEMBL160027)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451503BDBM50451503(CHEMBL12513)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204862BDBM50204862(N-[2-(4-Benzyl-piperidin-1-ylmethyl)-3H-benzoimida...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibition of Glu/Gly stimulated [Ca2+] influx in LtK-cells expressing the hNR1a/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50451780BDBM50451780(CHEMBL161859)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 409275BDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: 2nMAssay Description:Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50140341BDBM50140341(6-(3-(4-(4-fluorobenzyl)piperidin-1-yl)prop-1-ynyl...)
Affinity DataIC50: 2nMAssay Description:Binding affinity against NR1A/2B receptor in rat brains by [3H]ifenprodil displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50038168BDBM50038168(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Affinity DataIC50: 2nMAssay Description:In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membrane...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 21398BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50502547BDBM50502547(CHEMBL4581662)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50038168BDBM50038168(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for its ability to displace [3H]-L-689,560 from rat cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50471528BDBM50471528(CHEMBL168394)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50149693BDBM50149693(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215284BDBM50215284(2-(N-(7-chloro-6-methyl-2,3-dioxo-1,2,3,4-tetrahyd...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50215283BDBM50215283(2-(N-(6,7-dichloro-2,3-dioxo-1,2,3,4-tetrahydroqui...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human NMDA NR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Tenacia Biotechnology (Hong Kong) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50038168BDBM50038168(7-Chloro-4-hydroxy-3-(3-phenoxy-phenyl)-1H-quinoli...)
Affinity DataIC50: 2nMAssay Description:Inhibition of the binding of [3H]L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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