Compile Data Set for Download or QSAR
Report error Found 3762 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1'
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506874BDBM50506874(CHEMBL4161103)
Affinity DataIC50: 0.0300nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50570217BDBM50570217(CHEMBL4863423)
Affinity DataIC50: 0.0400nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514163BDBM50514163(CHEMBL4568985)
Affinity DataIC50: 0.0700nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 0.220nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 0.260nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50567579BDBM50567579(Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532707BDBM50532707(CHEMBL4585968)
Affinity DataEC50:  0.600nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532707BDBM50532707(CHEMBL4585968)
Affinity DataEC50:  0.600nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514163BDBM50514163(CHEMBL4568985)
Affinity DataIC50: 0.640nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 1000 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 0.710nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514158BDBM50514158(CHEMBL4526913)
Affinity DataIC50: 0.780nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50570217BDBM50570217(CHEMBL4863423)
Affinity DataIC50: 0.790nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565052BDBM50565052(CHEMBL4792609)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565051BDBM50565051(CHEMBL4783930)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565051BDBM50565051(CHEMBL4783930)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565052BDBM50565052(CHEMBL4792609)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50570217BDBM50570217(CHEMBL4863423)
Affinity DataIC50: 0.890nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532714BDBM50532714(CHEMBL4458009)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532714BDBM50532714(CHEMBL4458009)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532704BDBM50532704(CHEMBL4434729)
Affinity DataEC50:  0.970nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532704BDBM50532704(CHEMBL4434729)
Affinity DataEC50:  0.970nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238974BDBM50238974(CHEMBL4085670)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ABCB1 in human MCF7/ADR cells assessed as potentiation of vinblastine-induced cytotoxicity by measuring vinblastine IC50 at IC10 after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532706BDBM50532706(CHEMBL4547419)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532706BDBM50532706(CHEMBL4547419)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as decrease in calcein-AM transport after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621805BDBM50621805(CHEMBL5429850)
Affinity DataIC50: 1.40nMAssay Description:Negative allosteric modulator activity at P-gp in human LCC6MDR cells overexpressing P-gp assessed as reversal of P-gp mediated PTX resistance by mea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506874BDBM50506874(CHEMBL4161103)
Affinity DataIC50: 1.5nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50201796BDBM50201796(CHEBI:5677 | Hernandezine)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 500 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581481BDBM50581481(CHEMBL5089855)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514163BDBM50514163(CHEMBL4568985)
Affinity DataIC50: 1.90nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651337BDBM50651337(CHEMBL5631325)
Affinity DataEC50:  2nMAssay Description:Inhibition of MDR1 (unknown origin) overexpressed in MDCK cells using Calcein-AM as substrate preincubated for 30 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514161BDBM50514161(CHEMBL4469705)
Affinity DataIC50: 2nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621799BDBM50621799(CHEMBL5439145)
Affinity DataIC50: 2.10nMAssay Description:Negative allosteric modulator activity at P-gp in human LCC6MDR cells overexpressing P-gp assessed as reversal of P-gp mediated PTX resistance by mea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 2.10nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581480BDBM50581480(CHEMBL5088809)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506874BDBM50506874(CHEMBL4161103)
Affinity DataIC50: 2.20nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50565052BDBM50565052(CHEMBL4792609)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621802BDBM50621802(CHEMBL5408118)
Affinity DataIC50: 2.30nMAssay Description:Negative allosteric modulator activity at P-gp in human LCC6MDR cells overexpressing P-gp assessed as reversal of P-gp mediated PTX resistance by mea...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506874BDBM50506874(CHEMBL4161103)
Affinity DataIC50: 2.40nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091138BDBM50091138(CHEMBL3582168)
Affinity DataIC50: 2.70nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514158BDBM50514158(CHEMBL4526913)
Affinity DataIC50: 2.90nMAssay Description:Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxici...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81939BDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 3nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091264BDBM50091264(CHEMBL3582155)
Affinity DataIC50: 3nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50651344BDBM50651344(CHEMBL5631270)
Affinity DataEC50:  3nMAssay Description:Inhibition of MDR1 (unknown origin) overexpressed in MDCK cells using Calcein-AM as substrate preincubated for 30 mins followed by substrate addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50238973BDBM50238973(CHEMBL4064097)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of ABCB1 in human MCF7/ADR cells assessed as potentiation of vinblastine-induced cytotoxicity by measuring vinblastine IC50 at IC10 after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 3.30nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075373BDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 3.30nMAssay Description:Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50091087BDBM50091087(CHEMBL3582156)
Affinity DataIC50: 3.30nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50022815BDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of P-gp in human CEM cells incubated for 15 mins by calcein-AM efflux methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetATP-dependent translocase ABCB1(Human)
Yantai University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621798BDBM50621798(CHEMBL5403208)
Affinity DataIC50: 3.5nMAssay Description:Negative allosteric modulator activity at human P-gp G1114V mutant expressed in HEK293FT cells assessed as reversal of P-gp mediated PTX resistance b...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
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