Compile Data Set for Download or QSAR
Report error Found 202 Enz. Inhib. hit(s) with Target = 'Non-specific protein-tyrosine kinase [T818I]'
TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196624BDBM196624(US9670214, TABLE 16.73)
Affinity DataIC50: 386nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328135BDBM50328135(N-(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin...)
Affinity DataIC50: 600nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328121BDBM50328121(1-(pyridin-3-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 600nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196297BDBM196297(US9670214, TABLE 13.9)
Affinity DataIC50: 621nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196573BDBM196573(US9670214, TABLE 16.22)
Affinity DataIC50: 810nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196531BDBM196531(US9670214, TABLE 14.10)
Affinity DataIC50: 895nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328151BDBM50328151(4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataIC50: 1.05E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196304BDBM196304(US9670214, TABLE 13.10)
Affinity DataIC50: 1.21E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328138BDBM50328138((4-methylpiperazin-1-yl)(4-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 1.25E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328134BDBM50328134(2-(pyridin-3-ylmethyl)-N-(4-(trifluoromethoxy)phen...)
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196613BDBM196613(US9670214, TABLE 16.62)
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196563BDBM196563(US9670214, TABLE 16.12)
Affinity DataIC50: 1.41E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196556BDBM196556(US9670214, TABLE 16.5)
Affinity DataIC50: 1.45E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196592BDBM196592(US9670214, TABLE 16.41)
Affinity DataIC50: 1.48E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196167BDBM196167(US9670214, TABLE 10.15)
Affinity DataIC50: 1.50E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196197BDBM196197(US9670214, TABLE 10.29)
Affinity DataIC50: 1.50E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196597BDBM196597(US9670214, TABLE 16.46)
Affinity DataIC50: 1.55E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328156BDBM50328156(6-(1-isobutyl-1H-pyrazol-4-yl)-N-(4-(trifluorometh...)
Affinity DataIC50: 1.55E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196412BDBM196412(US9670214, TABLE 14.6)
Affinity DataIC50: 1.56E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196571BDBM196571(US9670214, TABLE 16.20)
Affinity DataIC50: 1.66E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196574BDBM196574(US9670214, TABLE 16.23)
Affinity DataIC50: 1.85E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196555BDBM196555(US9670214, TABLE 16.4)
Affinity DataIC50: 1.85E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196402BDBM196402(US9670214, TABLE 14.1)
Affinity DataIC50: 1.91E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196341BDBM196341(US9670214, TABLE 13.13)
Affinity DataIC50: 1.92E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196196BDBM196196(US9670214, TABLE 10.28)
Affinity DataIC50: 2.03E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196269BDBM196269(US9670214, TABLE 12.11)
Affinity DataIC50: 2.07E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196398BDBM196398(US9670214, TABLE 13.18)
Affinity DataIC50: 2.10E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196554BDBM196554(US9670214, TABLE 16.3)
Affinity DataIC50: 2.13E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196568BDBM196568(US9670214, TABLE 16.17)
Affinity DataIC50: 2.18E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196570BDBM196570(US9670214, TABLE 16.19)
Affinity DataIC50: 2.25E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328188BDBM50328188(piperazin-1-yl(4-(4-(trifluoromethoxy)phenylamino)...)
Affinity DataIC50: 2.30E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 195900BDBM195900(US9670214, TABLE 10.13)
Affinity DataIC50: 2.36E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196176BDBM196176(US9670214, TABLE 10.19)
Affinity DataIC50: 2.40E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196173BDBM196173(US9670214, TABLE 10.16)
Affinity DataIC50: 2.40E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328124BDBM50328124(1-tert-butyl-N-(4-(trifluoromethoxy)phenyl)-1H-pyr...)
Affinity DataIC50: 2.60E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196566BDBM196566(US9670214, TABLE 16.15)
Affinity DataIC50: 2.63E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196262BDBM196262(US9670214, TABLE 12.4)
Affinity DataIC50: 2.79E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196569BDBM196569(US9670214, TABLE 16.18)
Affinity DataIC50: 2.89E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196175BDBM196175(US9670214, TABLE 10.18)
Affinity DataIC50: 2.90E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196603BDBM196603(US9670214, TABLE 16.52)
Affinity DataIC50: 3.00E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328132BDBM50328132(2-(4-(4-(trifluoromethoxy)phenylamino)-2H-pyrazolo...)
Affinity DataIC50: 3.10E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328137BDBM50328137(6-(1-methyl-1H-pyrazol-4-yl)-N-(4-(trifluoromethox...)
Affinity DataIC50: 3.10E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196268BDBM196268(US9670214, TABLE 12.10)
Affinity DataIC50: 3.14E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196410BDBM196410(US9670214, TABLE 14.4)
Affinity DataIC50: 3.17E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196578BDBM196578(US9670214, TABLE 16.27)
Affinity DataIC50: 3.18E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196590BDBM196590(US9670214, TABLE 16.39)
Affinity DataIC50: 3.27E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196582BDBM196582(US9670214, TABLE 16.31)
Affinity DataIC50: 3.39E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196252BDBM196252(US9670214, TABLE 10.47)
Affinity DataIC50: 3.53E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 50328184BDBM50328184((4-(4-(trifluoromethoxy)phenylamino)thieno[2,3-d]p...)
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 196610BDBM196610(US9670214, TABLE 16.59)
Affinity DataIC50: 3.74E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
US Patent

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