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Found 192 with Last Name = 'hamann' and Initial = 'a'
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299858(1-(3,4-Dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149365(US8962860, 9)
Affinity DataKi:  3.24nM ΔG°:  -49.3kJ/mole IC50:  3.08nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149363(US8962860, 6)
Affinity DataKi:  3.80nM ΔG°:  -48.9kJ/mole IC50:  234nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149366(US8962860, 11)
Affinity DataKi:  4.13nM ΔG°:  -48.7kJ/mole IC50:  48nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149358(US8962860, 1)
Affinity DataKi:  6.07nM ΔG°:  -47.7kJ/mole IC50:  69.7nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299853(1-(3,4-Dimethoxyphenyl)-3-(3-(5-methyl-1H-imidazol...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149375(US8962860, 42)
Affinity DataKi:  6.49nM ΔG°:  -47.5kJ/mole IC50:  24nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM50240418(CHEMBL4096803)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected Sf9 insect cells using (MCA)-EDEDED-(K-epsilon-dnp) as substrate by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM124974(US8772508, 8)
Affinity DataKi:  11nM IC50:  580nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149371(US8962860, 16)
Affinity DataKi:  13.6nM ΔG°:  -45.7kJ/mole IC50:  128nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299845(3-[3-(5-Methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2...)
Affinity DataKi:  17nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149376(US8962860, 43)
Affinity DataKi:  17.7nM ΔG°:  -45.0kJ/mole IC50:  326nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299844(2,3-Dihydro-3-(3-(5-methyl-1H-imidazol-1-yl)propyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299847(6-Benzyl-2,3-dihydro-3-(3-(5-methyl-1H-imidazol-1-...)
Affinity DataKi:  20nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149369(US8962860, 14)
Affinity DataKi:  21.7nM ΔG°:  -44.5kJ/mole IC50:  173nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM50240455(CHEMBL1253351)
Affinity DataKi:  22nMAssay Description:Inhibition of recombinant human meprin beta expressed in baculovirus infected Sf9 insect cells using (MCA)-EDEDED-(K-epsilon-dnp) as substrate by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299866(CHEMBL578153 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  34nM IC50:  430nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299866(CHEMBL578153 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  34nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149362(US8962860, 5)
Affinity DataKi:  34.8nM ΔG°:  -43.3kJ/mole IC50:  182nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149367(US8962860, 12)
Affinity DataKi:  36nM ΔG°:  -43.2kJ/mole IC50:  523nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299846(3-[3-(5-Methyl-1H-imidazol-1-yl)propyl]-2-thioxo-2...)
Affinity DataKi:  39nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299867(CHEMBL565907 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  41nM IC50:  230nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299850(1-(3,4-Dimethoxyphenyl)-N-(3-(4-methyl-1H-imidazol...)
Affinity DataKi:  41nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149359(US8962860, 2)
Affinity DataKi:  41.3nM ΔG°:  -42.9kJ/mole IC50:  741nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299867(CHEMBL565907 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  42nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149368(US8962860, 13)
Affinity DataKi:  42.8nM ΔG°:  -42.8kJ/mole IC50:  298nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299864(CHEMBL574357 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  44nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149373(US8962860, 40)
Affinity DataKi:  45.9nM ΔG°:  -42.6kJ/mole IC50:  256nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149360(US8962860, 3)
Affinity DataKi:  48nM ΔG°:  -42.5kJ/mole IC50:  34.9nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299865(CHEMBL567406 | N-(-1-(3-(5-Methyl-1H-imidazol-1-yl...)
Affinity DataKi:  51nM IC50:  320nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299865(CHEMBL567406 | N-(-1-(3-(5-Methyl-1H-imidazol-1-yl...)
Affinity DataKi:  51nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149361(US8962860, 4)
Affinity DataKi:  51.6nM ΔG°:  -42.3kJ/mole IC50:  560nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM124971(US8772508, 2)
Affinity DataKi:  55nM IC50:  530nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149370(US8962860, 15)
Affinity DataKi:  58.5nM ΔG°:  -42.0kJ/mole IC50:  540nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM7918(1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  60nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299849(1-(3,4-Dimethoxyphenyl)-3-(3-(4-methyl-1H-imidazol...)
Affinity DataKi:  60nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299863(2-Cyano(3,4,5-trimethoxyphenyl)-3-(3-(5-methyl-1H-...)
Affinity DataKi:  61nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299861(2-Cyano-1-[3-(5-methyl-1H-imidazol-1-yl)propyl]-4-...)
Affinity DataKi:  65nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149364(US8962860, 7)
Affinity DataKi:  65.5nM ΔG°:  -41.7kJ/mole IC50:  430nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM124975(US8772508, 9)
Affinity DataKi:  67nM IC50:  340nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299868(CHEMBL565908 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  67nM IC50:  460nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299868(CHEMBL565908 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  67nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM124973(US8772508, 4)
Affinity DataKi:  76nM IC50:  730nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM50299864(CHEMBL574357 | N-(1-(3-(5-Methyl-1H-imidazol-1-yl)...)
Affinity DataKi:  80nM IC50:  340nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299859(2-Cyano(3-(5-methyl-1H-imidazol-1-yl)propyl)-3-(3,...)
Affinity DataKi:  82nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299848(2,3-Dihydro-6-methyl-3-(3-(5-methyl-1H-imidazol-1-...)
Affinity DataKi:  83nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM149374(US8962860, 41)
Affinity DataKi:  85.3nM ΔG°:  -41.0kJ/mole IC50:  485nMT: 2°CAssay Description:This novel assay was used to determine the kinetic parameters for most of the QC substrates. QC activity was analyzed spectrophotometrically using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM7937(1-(3,4-dimethoxyphenyl)-N-[3-(1H-imidazol-1-yl)pro...)
Affinity DataKi:  90nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Homo sapiens (Human))
Probiodrug

US Patent
LigandPNGBDBM124972(US8772508, 3)
Affinity DataKi:  96nM IC50:  620nMpH: 8.0Assay Description:All measurements were performed with a BioAssay Reader HTS-7000Plus for microplates (Perkin Elmer) at 30C. QC activity was evaluated fluorometrically...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Probiodrug

Curated by ChEMBL
LigandPNGBDBM50299862((3-(5-Methyl-1H-imidazol-1-yl)propyl)-2-cyano-3-(2...)
Affinity DataKi:  130nMAssay Description:Inhibition of human glutaminyl cyclase expressed in Pichia pastoris by pGAP coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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