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Found 501 with Last Name = 'pearce' and Initial = 'd'
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295778(2-(2,6-dimethylphenoxy)-5-(4-(6-methoxypyridin-3-y...)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262270(2-(4-fluoro-2-methylphenyl)-5-(4-(6-methoxypyridin...)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295779(2-(2-chloro-3,6-difluorophenoxy)-5-(4-(6-methoxypy...)
Affinity DataKi:  8.80nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295777(2-(4-fluoro-2-methylphenoxy)-5-(4-(6-methoxypyridi...)
Affinity DataKi:  9.40nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295772(2-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-tri...)
Affinity DataKi:  12.5nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295776(2-(3-fluoro-2-methylphenoxy)-5-(4-(6-methoxypyridi...)
Affinity DataKi:  14.6nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257637(1-(4-aminopyridin-2-yl)-4-phenyl-N-(quinolin-2-yl)...)
Affinity DataKi:  17nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257723(2-(3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine...)
Affinity DataKi:  18nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295771(2-(2-chlorophenoxy)-5-(4-(6-methoxypyridin-3-yl)-5...)
Affinity DataKi:  23.6nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257639((1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4-yl)(3...)
Affinity DataKi:  35nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295780(2-(2,4-dichlorophenoxy)-5-(4-(6-methoxypyridin-3-y...)
Affinity DataKi:  37.5nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295773(2-(2-ethylphenoxy)-5-(4-(6-methoxypyridin-3-yl)-5-...)
Affinity DataKi:  52.3nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257684(CHEMBL495346 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Affinity DataKi:  82nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257638(CHEMBL493743 | ethyl 4-(1-(4-aminopyridin-2-yl)-4-...)
Affinity DataKi:  169nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295775(2-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-tri...)
Affinity DataKi:  198nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257683(1-(4-aminopyridin-2-yl)-N-(4-methoxybenzyl)-4-phen...)
Affinity DataKi:  201nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295774(2-(2-methoxyphenoxy)-5-(4-(6-methoxypyridin-3-yl)-...)
Affinity DataKi:  253nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257685(CHEMBL492330 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Affinity DataKi:  343nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295770(2-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-tri...)
Affinity DataKi:  350nMAssay Description:Antagonist activity at human cloned oxytocin receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262270(2-(4-fluoro-2-methylphenyl)-5-(4-(6-methoxypyridin...)
Affinity DataKi:  388nMAssay Description:Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257833(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-benzyl...)
Affinity DataKi:  518nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257686(CHEMBL522317 | N-(1-(4-aminopyridin-2-yl)-4-phenyl...)
Affinity DataKi:  548nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257834(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-(cyclo...)
Affinity DataKi:  746nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257831(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-(4-met...)
Affinity DataKi:  865nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257832(3-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-1-phenyl...)
Affinity DataKi:  903nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257781(2-(3-(3-methoxyphenyl)-3-methylazetidin-1-yl)pyrid...)
Affinity DataKi:  1.84E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295770(2-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-tri...)
Affinity DataKi:  2.32E+3nMAssay Description:Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295770(2-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-tri...)
Affinity DataKi:  2.32E+3nMAssay Description:Antagonist activity at human cloned vasopressin V1A receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257780((S)-1'-(4-aminopyridin-2-yl)-N,N-dimethyl-2,3-dihy...)
Affinity DataKi:  4.71E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257782(CHEMBL493515 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Affinity DataKi:  5.03E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257784(CHEMBL493517 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Affinity DataKi:  9.69E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262270(2-(4-fluoro-2-methylphenyl)-5-(4-(6-methoxypyridin...)
Affinity DataKi: >1.00E+4nMAssay Description:Antagonist activity at human cloned vasopressin V2 receptor by cell based beta-lactamase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257719((S)-N-(1-(4-aminopyridin-2-yl)-4-phenylpiperidin-4...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257830(CHEMBL493781 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257783(CHEMBL493516 | N-(1-(4-aminopyridin-2-yl)piperidin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50257722((S)-1'-(4-aminopyridin-2-yl)-N,N-diethyl-3H-spiro[...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50187693(CHEMBL3186509)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ATX (unknown origin) assessed as decrease in choline releaseMore data for this Ligand-Target Pair
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM322065(1-(4-(5-(1H-1,2,3-Triazol-4-yl)pentyl)piperidin-1-...)
Affinity DataIC50:  2nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM321944((E)-1-(4-((1-Methyl-1H-pyrazol-4-yl)methyl)piperaz...)
Affinity DataIC50:  2nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM321962((R,E)-3-(2-((5-Methyl-2H-tetrazol-2-yl)methyl)-4-(...)
Affinity DataIC50:  2nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322065(1-(4-(5-(1H-1,2,3-Triazol-4-yl)pentyl)piperidin-1-...)
Affinity DataIC50:  2nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321944((E)-1-(4-((1-Methyl-1H-pyrazol-4-yl)methyl)piperaz...)
Affinity DataIC50:  2nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321962((R,E)-3-(2-((5-Methyl-2H-tetrazol-2-yl)methyl)-4-(...)
Affinity DataIC50:  2nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322066(1-(4-(5-(1H-1,2,3-Triazol-4-yl)pentyl)piperidin-1-...)
Affinity DataIC50:  2.40nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM322066(1-(4-(5-(1H-1,2,3-Triazol-4-yl)pentyl)piperidin-1-...)
Affinity DataIC50:  2.40nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM322063((E)-N-(1-(3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-y...)
Affinity DataIC50:  3.10nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM241106(US9409895, 17 | US9630945, 17)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of ATX (unknown origin) assessed as decrease in choline releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322063((E)-N-(1-(3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-y...)
Affinity DataIC50:  3.10nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM241109(US9409895, 20 | US9630945, 20)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of ATX (unknown origin) assessed as decrease in choline releaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAtaxin-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM321991((E)-1-(4-((1-Methyl-1H-pyrazol-3-yl)methyl)piperaz...)
Affinity DataIC50:  3.5nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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