Affinity DataKi: 0.300nMAssay Description:Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPRMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University
Curated by ChEMBL
Georgia State University
Curated by ChEMBL
Affinity DataKi: 8.40E+3nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University
Curated by ChEMBL
Georgia State University
Curated by ChEMBL
Affinity DataKi: 1.13E+4nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University
Curated by ChEMBL
Georgia State University
Curated by ChEMBL
Affinity DataKi: 2.97E+4nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University
Curated by ChEMBL
Georgia State University
Curated by ChEMBL
Affinity DataKi: >2.57E+5nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
The Ohio State University
Curated by ChEMBL
The Ohio State University
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes
Curated by ChEMBL
National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 152nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening
Curated by ChEMBL
Chinese National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair