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Found 336 with Last Name = 'el-subbagh' and Initial = 'hi'
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363963(CHEMBL1949725)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363963(CHEMBL1949725)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363966(CHEMBL1949728)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363966(CHEMBL1949728)
Affinity DataKi:  11.4nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363963(CHEMBL1949725)
Affinity DataKi:  85.3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363967(CHEMBL1949729)
Affinity DataKi:  91.4nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363967(CHEMBL1949729)
Affinity DataKi:  114nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363966(CHEMBL1949728)
Affinity DataKi:  268nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363963(CHEMBL1949725)
Affinity DataKi:  304nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363964(CHEMBL1949726)
Affinity DataKi:  389nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363964(CHEMBL1949726)
Affinity DataKi:  640nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363965(CHEMBL1949727)
Affinity DataKi:  657nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363966(CHEMBL1949728)
Affinity DataKi:  681nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363967(CHEMBL1949729)
Affinity DataKi:  2.92E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363967(CHEMBL1949729)
Affinity DataKi:  4.68E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363965(CHEMBL1949727)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363964(CHEMBL1949726)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363965(CHEMBL1949727)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363964(CHEMBL1949726)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Martin-Luther-Universit£T Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50363965(CHEMBL1949727)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50448052(CHEMBL3115740)
Affinity DataIC50:  4nMAssay Description:Inhibition of bovine liver DHFR measured for every 1 min of 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bovine liver DHFR preincubated for 2 mins followed by addition of FH2 as substrate and NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bovine liver DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM226165(N'-[4-Methoxybenzylidene-2-(6-chloro)-3-(4-met...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:The assay mixture contained 50 μM Tris-HCl buffer (pH 7.4), 50 μM NADPH, 10 μl DMSO or the same volume of DMSO solution containing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50196309(CHEMBL3929338)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine liver DHFR preincubated for 2 mins followed by addition of FH2 as substrate and NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603507(CHEMBL5169560)
Affinity DataIC50:  16nMAssay Description:Inhibition of human plasma BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50196287(CHEMBL3936506)
Affinity DataIC50:  20nMAssay Description:Inhibition of bovine liver DHFR preincubated for 2 mins followed by addition of FH2 as substrate and NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50438444(CHEMBL2414370)
Affinity DataIC50:  30nMAssay Description:Inhibition of bovine liver DHFR measured every 1 min for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603482(CHEMBL5199487)
Affinity DataIC50:  34nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant human HER2 incubated for 40 to 45 mins and measured after 15 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  54nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603488(CHEMBL5205489)
Affinity DataIC50:  56nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50448057(CHEMBL3115735)
Affinity DataIC50:  60nMAssay Description:Inhibition of bovine liver DHFR measured for every 1 min of 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli incubated for 15 mins and measured by ELISAMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603485(CHEMBL5172647)
Affinity DataIC50:  62nMAssay Description:Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  62nMAssay Description:Inhibition of recombinant human EGFR incubated for 40 to 45 mins and measured after 15 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50590837(CHEMBL5173449)
Affinity DataIC50:  78nMAssay Description:Inhibition of recombinant human HER2 incubated for 40 to 45 mins and measured after 15 mins by Kinase-Glo Max assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine liver DHFR measured every 1 min for 10 minsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine DHFR after 2 minsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMpH: 7.4 T: 2°CAssay Description:The assay mixture contained 50 μM Tris-HCl buffer (pH 7.4), 50 μM NADPH, 10 μl DMSO or the same volume of DMSO solution containing the...More data for this Ligand-Target Pair
In DepthDetails PDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine liver DHFR measured for every 1 min of 10 minsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human DHFR after 2 minsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine DHFR after 2 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human plasma BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  88nMAssay Description:Inhibition of DHFR (unknown origin) incubated for 2 to 5 mins by absorbance based analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50448056(CHEMBL3115736)
Affinity DataIC50:  90nMAssay Description:Inhibition of bovine liver DHFR measured for every 1 min of 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50603507(CHEMBL5169560)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  99nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50196313(CHEMBL3914501)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine liver DHFR preincubated for 2 mins followed by addition of FH2 as substrate and NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Future University

Curated by ChEMBL
LigandPNGBDBM50196288(CHEMBL3959539)
Affinity DataIC50:  100nMAssay Description:Inhibition of bovine liver DHFR preincubated for 2 mins followed by addition of FH2 as substrate and NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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