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Found 348 with Last Name = 'jakubowski' and Initial = 'ja'
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061849((S)-2-Benzenesulfonylamino-3-{3-[(5-carbamimidoyl-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061839(2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061840((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061847((S)-2-(Butane-1-sulfonylamino)-3-{3-[(5-carbamimid...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061859(2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50082930(CHEMBL117662 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061862((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50082933(CHEMBL323720 | [6-(4-Carbamimidoyl-benzoylamino)-c...)
Affinity DataIC50:  2nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072779((E)-7-{4-[4-(2-Phenoxy-ethylcarbamoyl)-oxazol-2-yl...)
Affinity DataIC50:  2.60nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072778((E)-7-(4-{4-[3-(4-Methoxy-phenyl)-propylcarbamoyl]...)
Affinity DataIC50:  2.70nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058914(CHEMBL303597 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of fibrinogen binding to purified Human alphaIIb-beta3 integrin in ELISA with 1% bovine serum albumin (BSA)More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085605(CHEMBL126411 | [6-(4-Carbamimidoyl-2-fluoro-benzoy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058928(CHEMBL292795 | [6-(4-Carbamimidoyl-phenylcarbamoyl...)
Affinity DataIC50:  3nMAssay Description:Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085612(CHEMBL126485 | [6-(4-Carbamimidoyl-2,6-difluoro-be...)
Affinity DataIC50:  5nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290317(4-{1-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA testMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290324(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290319(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)
Affinity DataIC50:  8nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA testMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072788((E)-7-{4-[4-((1R,2S)-2-Phenyl-cyclopropylcarbamoyl...)
Affinity DataIC50:  8.5nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072788((E)-7-{4-[4-((1R,2S)-2-Phenyl-cyclopropylcarbamoyl...)
Affinity DataIC50:  8.5nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085611(CHEMBL127680 | {6-[(6-Carbamimidoyl-pyridine-3-car...)
Affinity DataIC50:  9nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072785((E)-7-[4-(4-Phenethylcarbamoyl-oxazol-2-yl)-phenyl...)
Affinity DataIC50:  9.40nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085614(CHEMBL338485 | [6-(4-Carbamimidoyl-2-chloro-benzoy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072787((E)-7-(4-{4-[3-(1-Cyclohexyl-ethoxy)-propylcarbamo...)
Affinity DataIC50:  11.5nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003795(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)
Affinity DataIC50:  14.7nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071134((E)-7-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50059694(7-[(6-Carbamimidoyl-1H-indazole-3-carbonyl)-amino]...)
Affinity DataIC50:  20nMAssay Description:Antagonism of fibrinogen binding to a purified human fibrinogen receptor preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061841(3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amin...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061848(3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061864(3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amin...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity of fibrinogen binding to purified immobilized glycoprotein (fibrinogen receptor).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071145((Z)-7-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290325(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)
Affinity DataIC50:  24nMAssay Description:Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290325(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)
Affinity DataIC50:  24nMAssay Description:Inhibition of fibrinogen binding to purified human alpha IIb beta3 integrin by 50% in an ELISA testMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071142((E)-7-[4-(4-Benzylcarbamoyl-oxazol-2-yl)-phenyl]-7...)
Affinity DataIC50:  24.7nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061862((S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of 20 uM ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071131((E)-7-{4-[4-(Cyclopropylmethyl-carbamoyl)-oxazol-2...)
Affinity DataIC50:  25nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071131((E)-7-{4-[4-(Cyclopropylmethyl-carbamoyl)-oxazol-2...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071142((E)-7-[4-(4-Benzylcarbamoyl-oxazol-2-yl)-phenyl]-7...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50085607(CHEMBL126365 | [1-Oxo-6-((E)-3-piperidin-4-yl-acry...)
Affinity DataIC50:  26nMAssay Description:Inhibition of fibrinogen binding to purified human GPIIb-IIIa in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072780((E)-7-(4-{4-[3-(4-Methoxy-cyclohexyl)-propylcarbam...)
Affinity DataIC50:  28.7nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071141((E)-7-[4-(4-Pentylcarbamoyl-oxazol-2-yl)-phenyl]-7...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071141((E)-7-[4-(4-Pentylcarbamoyl-oxazol-2-yl)-phenyl]-7...)
Affinity DataIC50:  31.2nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072786((E)-7-{4-[4-(2-Cyclohexyloxy-ethylcarbamoyl)-oxazo...)
Affinity DataIC50:  33nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058924(CHEMBL68183 | [6-(4-Carbamimidoyl-phenylethynyl)-1...)
Affinity DataIC50:  33nMAssay Description:Concentration required to reduce binding of fibrinogen to purified Fibrinogen Receptor by 50% using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061849((S)-2-Benzenesulfonylamino-3-{3-[(5-carbamimidoyl-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of 20 uM ADP-induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061847((S)-2-(Butane-1-sulfonylamino)-3-{3-[(5-carbamimid...)
Affinity DataIC50:  35nMAssay Description:Inhibition of platelet aggregation induced by 20 microM adenosine 5'-diphosphate (ADP) in human platelet rich plasma (h-PRP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50031565((S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propion...)
Affinity DataIC50:  35nMAssay Description:Inhibition ADP-induced (fibrinogen-mediated) platelet aggregation in human platelet-rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072783((E)-7-{4-[1-(4-Cyclohexyl-butylcarbamoyl)-vinylcar...)
Affinity DataIC50:  35.7nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50072781((E)-7-{4-[4-(2-Cyclohexylmethoxy-ethylcarbamoyl)-o...)
Affinity DataIC50:  36.7nMAssay Description:In vitro for inhibitory activity against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071140((E)-8-{4-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50290325(3-[6-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro...)
Affinity DataIC50:  40nMAssay Description:Inhibition of ADP induced platelet aggregation in human platelet-rich plasma (PRP).More data for this Ligand-Target Pair
In DepthDetails Article
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