Affinity DataKi: 29nMAssay Description:Mixed/noncompetitive inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Mixed/noncompetitive inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataKi: 627nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.94E+3nMAssay Description:Displacement of [3H]furoyl-LIGRL-NH2 from human protease-activated receptor 2 in NCTC-2544 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of CAMK2b (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.367nMAssay Description:Inhibition of HIPK1 (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.370nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
TargetMisshapen-like kinase 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.470nMAssay Description:Inhibition of MINK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.473nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
TargetPhosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of PHKg2 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.640nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.720nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of LCK (unknown origin) after 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea University Of Science And Technology (Ust)
Curated by ChEMBL
Korea University Of Science And Technology (Ust)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]-diprenorphine binding to kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human mPGES-1 assessed as reduction in PGE2 productionMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.31nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Affinity DataIC50: 1.58nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.75nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataIC50: 2.06nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.08nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G1/S-specific cyclin- 1(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CDK1/cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of c-SRC (unknown origin)More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Korea Institute of Science & Technology (Kist)
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.37nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.46nMAssay Description:Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) using Ser/Thr 03 as substrate after 1 hr in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)
Curated by ChEMBL
National Research Centre (Nrc)
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair