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Found 66 with Last Name = 'kelley' and Initial = 'mr'
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303973((E)-N-(2-Hydroxyethyl)-3-(3-chloro-1,4-dioxonaphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303972((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methoxyet...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303967((E)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303964((E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylp...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303965((E)-3-(3-Methylthio-1,4-naphthoquinon-2-yl)-2-meth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530042(CHEMBL4517868)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530042(CHEMBL4517868)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530037(CHEMBL4473257)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530037(CHEMBL4473257)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530043(CHEMBL4458126)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530043(CHEMBL4458126)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530040(CHEMBL4581229)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530040(CHEMBL4581229)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303968((Z)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303969((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530038(CHEMBL4465479)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530029(CHEMBL4567730)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530038(CHEMBL4465479)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530029(CHEMBL4567730)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530036(CHEMBL4465198)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530036(CHEMBL4465198)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530048(CHEMBL4460339)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530048(CHEMBL4460339)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303971((E)-2-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303959((E)-3-(3-Chloro-5,6-dimethoxy-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303957((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303962((E)-3-(1,4-Naphthoquinon-2-yl)-2-methylpropenoic a...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303966((E)-3-(3-Fluoro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303974(3-(3-Bromo-1,4-naphthoquinon-2-yl)-propionic Acid ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530041(CHEMBL4566116)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530041(CHEMBL4566116)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530049(CHEMBL4455293)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530049(CHEMBL4455293)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM119124((E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxocyclohexa-...)
Affinity DataIC50:  8.50E+3nMpH: 7.5Assay Description:E3330 or E3330-amide was preincubated with 2 μL of APE1 (reduced with 1.0 mM DTT for 10 min and then diluted to a concentration of 0.06 mM with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530046(CHEMBL4549101)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530046(CHEMBL4549101)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303955((E)-3-(5,6-Dimethoxy-3-methyl-14-dioxocyclohexa-25...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303970((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methoxye...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303960((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303961((E)-N-(2-Hydroxyethyl)-3-(5,6-dimethoxy-3-methyl-1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530047(CHEMBL4552083)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530047(CHEMBL4552083)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530039(CHEMBL4539845)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530039(CHEMBL4539845)
Affinity DataIC50:  1.21E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303958((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303963((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303955((E)-3-(5,6-Dimethoxy-3-methyl-14-dioxocyclohexa-25...)
Affinity DataIC50:  2.00E+4nMpH: 7.5Assay Description:E3330 or E3330-amide was preincubated with 2 μL of APE1 (reduced with 1.0 mM DTT for 10 min and then diluted to a concentration of 0.06 mM with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530031(CHEMBL4514209)
Affinity DataIC50:  2.65E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530031(CHEMBL4514209)
Affinity DataIC50:  2.65E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50530034(CHEMBL4457207)
Affinity DataIC50:  2.92E+4nMAssay Description:Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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