TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.140nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.165nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.270nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.530nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 0.75nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:ATP competitive inhibition of human Flt4More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:ATP competitive inhibition of human MLK1More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:ATP competitive inhibition of human Flt3 D835Y mutantMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:ATP competitive inhibition of human DYRK2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:ATP competitive inhibition of human MerMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:ATP competitive inhibition of human GSK3alphaMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 39nMAssay Description:ATP competitive inhibition of human c-Kit D816H mutantMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 44nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 47nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
Ligand Info
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 59nMAssay Description:ATP competitive inhibition of human ABL T315I mutantMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 82nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 93nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 105nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 115nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
Ligand Info
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 140nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 140nMAssay Description:Inhibition of human PI3K p110alpha/p85alphaMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 150nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 189nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 190nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
Ligand Info
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 190nMAssay Description:Inhibition of human SYKMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 530nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 650nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 785nMAssay Description:Inhibition of purified recombinant human full-length DNA-PK using EPPLSQEAFADLWKKK peptide as substrate measured after 2 hrs in presence of [gamma-33...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd
Curated by ChEMBL
Msd
Curated by ChEMBL
Affinity DataKi: 1.26E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1.35E+3nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Vertex Pharmaceuticals (Europe)
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of full-length ATM (unknown origin) using DPSVEPPLSQETFSDKKK peptide as substrate measured after 24 hrs in presence of [gamma-33P] ATP by ...More data for this Ligand-Target Pair