Compile Data Set for Download or QSAR
maximum 50k data
Found 474 with Last Name = 'moon' and Initial = 's'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50483880(CHEMBL1774642)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]PIB from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50483881(CHEMBL1774643)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]PIB from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PIB from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070476((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,6-difluoro-p...)
Affinity DataKi:  5nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50483880(CHEMBL1774642)
Affinity DataKi:  5.5nMAssay Description:Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50483881(CHEMBL1774643)
Affinity DataKi:  5.90nMAssay Description:Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070473((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,4-difluoro-p...)
Affinity DataKi:  12nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Seoul National University Bundang Hospital

Curated by ChEMBL
LigandPNGBDBM50483882(CHEMBL284575)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]TZDM from amyloid beta (1 to 42) aggregates in Alzheimer's disease-human brain homogenate after 3 hrs by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089503(2-[7,12,17-tri(2,5-hydroxyphenyl)-21,22,23,24-tetr...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089504((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,3,5-trifluor...)
Affinity DataKi:  2.85E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089505(2,7,12,17-tetra(3-fluoro-1-methyl-4-pyridiniumyl)-...)
Affinity DataKi:  3.06E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol-trisphosphate 3-kinase A(Homo sapiens (Human))
New York University

LigandPNGBDBM82310(Purine, 5)
Affinity DataKi:  4.30E+3nM ΔG°:  -31.9kJ/mole IC50:  1.02E+4nMpH: 8.0 T: 2°CAssay Description:IP3K reactions were carried out in a 100ul solution that contained Tris-Cl, EGTA, ATP, DTT, 2,3-diphosphoglycerate, D-l(1,4,5)P3, [3H]-l(1,4,5)P3 and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089507((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(3-fluoro-pyrid...)
Affinity DataKi:  5.08E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089502((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2,3,5,6-tetraf...)
Affinity DataKi:  7.29E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089510((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(3-fluoro-pheny...)
Affinity DataKi:  9.70E+3nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50070472((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-pentafluorophen...)
Affinity DataKi:  1.52E+4nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089509(2-[7,12,17-tri(2-hydroxyphenyl)-21,22,23,24-tetraa...)
Affinity DataKi:  1.83E+4nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089508(2-[7,12,17-tri(3-hydroxyphenyl)-21,22,23,24-tetraa...)
Affinity DataKi:  2.96E+4nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50089506((1Z,4Z,9Z,15Z)-5,10,15,20-Tetrakis-(2-fluoro-pheny...)
Affinity DataKi:  5.09E+4nMAssay Description:Inhibition constant (Ki) against electric eel Acetylcholinesterase as Km/Vmax versus inhibitor concentration replotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304788(CHEMBL594160 | methyl 4-(3-chloro-4-methoxybenzyla...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246252(CHEMBL521075 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246252(CHEMBL521075 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282973(4-Fluoro-N-{1-(4-fluoro-naphthalen-1-yl)-4-[4-(5-f...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304792(CHEMBL595104 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304790(CHEMBL595330 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304789(CHEMBL604271 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  1nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282974(CHEMBL58283 | N-{1-Cyclohexyl-4-[4-(5-fluoro-pyrim...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity towards serotonin 5-HT1A receptor by the displacement of [3H]-8-OH-DPAT from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282966(CHEMBL58282 | N-{1-Cyclohexyl-4-[4-(5-fluoro-pyrim...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity towards serotonin 5-HT1A receptor by the displacement of [3H]-8-OH-DPAT from rat hippocampusMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282962(1-(4-Fluoro-naphthalen-1-yl)-4-[4-(5-fluoro-pyrimi...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor by the displacement of [3H]-spiperone from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282958(1-Cyclohexyl-4-[4-(5-fluoro-pyrimidin-2-yl)-pipera...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor by the displacement of [3H]-spiperone from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282974(CHEMBL58283 | N-{1-Cyclohexyl-4-[4-(5-fluoro-pyrim...)
Affinity DataIC50: >2nMAssay Description:In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataIC50: <2nMAssay Description:Inhibitory activity against murine Prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...)
Affinity DataIC50:  2.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50426967(CHEMBL2325079 | PF-4693627)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304791(CHEMBL592986 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50304786(CHEMBL603422 | methyl 4-(3-chloro-4-methoxybenzyla...)
Affinity DataIC50:  3nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246104(CHEMBL512174 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  4nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246145(CHEMBL471702 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286098((R)-3-((7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50:  5.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50:  6nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246015(CHEMBL473301 | N-(3-chloro-4-methoxybenzyl)-7-chlo...)
Affinity DataIC50:  8nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM393885(US10597367, Example 182 | US9969726, Example 182)
Affinity DataIC50:  8.30nMAssay Description:Negative allosteric modulator activity at human recombinant mGlur2 expressed in HEK293 cells by calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286095((R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  8.5nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM50246199(CHEMBL488265 | N-(4-(3-chloro-4-methoxybenzylamino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Chong Kun Dang Research Institute

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  10nMAssay Description:Inhibition of bovine platelet PDE5More data for this Ligand-Target Pair
Displayed 1 to 50 (of 474 total ) | Next | Last >>
Jump to: