Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: <0.5nMAssay Description:Inhibition of BCL2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate measured every 30 secs for 15 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Competitive inhibition of recombinant human GST-tagged CK2alpha by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of recombinant human caspase 3 using Ac-Asp-Glu-Val-Asp-AFC as substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Displacement of biotin-labelled geldanamycin from human HSP90 (D9 to E236 residues) incubated for 3 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+3nMAssay Description:Inhibition of human HSP90 (D9 to E236 residues) by fluorescence spectroscopyMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate measured every 30 secs for 15 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+5nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6.80E+5nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataKi: 5.50E+6nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazineMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of human NMT1 by fluorescence methodMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:All kinase assays were performed as previously described5 at −4° C. in a final volume of 18 μL, containing 2 μL of compounds accordin...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant human DYRK1B in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant human DYRK1B in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant DyrK1b by fluorescence-based immunoassayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Saarland University
Curated by ChEMBL
Saarland University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant DyrK1b by fluorescence-based immunoassayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human recombinant DyrK1a by fluorescence-based immunoassayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human recombinant DyrK1a by fluorescence-based immunoassayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human DYRK1A in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human DYRK1A in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:All kinase assays were performed as previously described5 at −4° C. in a final volume of 18 μL, containing 2 μL of compounds accordin...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of MMP3 (unknown origin) using Ac-Pro-Leu-Gly-[2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt as substrate incubated for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:All kinase assays were performed as previously described5 at −4° C. in a final volume of 18 μL, containing 2 μL of compounds accordin...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:All kinase assays were performed as previously described5 at −4° C. in a final volume of 18 μL, containing 2 μL of compounds accordin...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:All kinase assays were performed as previously described5 at −4° C. in a final volume of 18 μL, containing 2 μL of compounds accordin...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of Serratia marcescens chitinase BMore data for this Ligand-Target Pair