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Found 193 with Last Name = 'prins' and Initial = 't'
TargetGenome polyprotein(Human rhinovirus B)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50065621(CHEMBL94688 | [(S)-1-((S)-1-{(S)-3-Carbamoyl-1-[2-...)
Affinity DataKi:  30nMAssay Description:Catalytic rate constant (Kobs/[I]) of the compound was evaluated against human rhinovirus (HRV) serotype 14 3C Protease (3CP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408099(CHEMBL57087)
Affinity DataKi:  120nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408102(CHEMBL55646)
Affinity DataKi:  150nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408104(CHEMBL292238)
Affinity DataKi:  200nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408110(CHEMBL293284)
Affinity DataKi:  220nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408096(CHEMBL301025)
Affinity DataKi:  350nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408101(CHEMBL293519)
Affinity DataKi:  370nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408094(CHEMBL59256)
Affinity DataKi:  390nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408105(CHEMBL294146)
Affinity DataKi:  550nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408100(CHEMBL57674)
Affinity DataKi:  570nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408103(CHEMBL293294)
Affinity DataKi:  790nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408107(CHEMBL56789)
Affinity DataKi:  6.50E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408097(CHEMBL56270)
Affinity DataKi:  7.20E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408109(CHEMBL54055)
Affinity DataKi:  8.40E+3nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408106(CHEMBL56927)
Affinity DataKi:  1.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408098(CHEMBL298828)
Affinity DataKi:  2.40E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408095(CHEMBL292166)
Affinity DataKi:  6.70E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408108(CHEMBL299276)
Affinity DataKi:  8.30E+4nMAssay Description:Apparent inhibition constant of Wild-type human recombinant FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319027((+/-)-3-(amino(2-(2-aminopyrimidin-4-yl)-3-methylb...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319021(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319025(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319031((+/-)-4-(5-(amino(phenyl)methyl)-3-methylbenzo[b]t...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319035((+/-)-4-(5-(1-aminobutyl)-3-methylbenzo[b]thiophen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319026((+/-)-4-(5-(amino(3-methoxyphenyl)methyl)-3-methyl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319037((+/-)-4-(5-(1-amino-3-methylbutyl)-3-methylbenzo[b...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319029((+/-)--4-(5-(amino(3-chlorophenyl)methyl)-3-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190964(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  38nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319030((+/-)--4-(5-(amino(m-tolyl)methyl)-3-methylbenzo[b...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319022(3-((2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thio...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319036((+/-)-4-(5-(1-amino-2-methylpropyl)-3-methylbenzo[...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319028((+/-)--4-(5-(amino(4-methoxyphenyl)methyl)-3-methy...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190967(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319034((+/-)-4-(5-(1-aminopropyl)-3-methylbenzo[b]thiophe...)
Affinity DataIC50:  140nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190951(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319018(4-(5-(3-methoxybenzyl)-3-methylbenzo[b]thiophen-2-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190956(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319024(3-(2-(2-aminopyrimidin-4-yl)-3-methylbenzo[b]thiop...)
Affinity DataIC50:  360nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319033((+/-)-4-(5-(1-aminoethyl)-3-methylbenzo[b]thiophen...)
Affinity DataIC50:  400nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190968(6-(3-fluoro-4-isopropoxyphenethyl)-6-cyclopentyl-d...)
Affinity DataIC50:  530nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190969(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-4-hy...)
Affinity DataIC50:  560nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319016(4-(5-benzyl-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  580nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190952(6-(4-ethoxy-3-fluorophenethyl)-6-cyclopentyl-dihyd...)
Affinity DataIC50:  790nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190957(6-(3-fluoro-4-methoxyphenethyl)-6-cyclopentyl-dihy...)
Affinity DataIC50:  890nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50078109(3-(4-Amino-2-tert-butyl-5-methyl-phenylsulfanyl)-6...)
Affinity DataIC50:  930nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190963(6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-dihy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319007(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-N-methy...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kalypsys

Curated by ChEMBL
LigandPNGBDBM50319006(4-(5-chloro-3-methylbenzo[b]thiophen-2-yl)pyrimidi...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ROCK1 assessed as ATP cunsumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190966(6-(4-isopropoxyphenethyl)-6-cyclopentyl-dihydro-3H...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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