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Found 476 with Last Name = 'ognyanov' and Initial = 'vi'
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50407003(CHEMBL2092837)
Affinity DataKi:  3.90E+3nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046068(1D-3-deoxy- 1D-myo-Inositol 1,4,5-trisphosphate)
Affinity DataKi:  1.15E+4nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50075183(1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...)
Affinity DataKi:  1.50E+4nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046075(1D-2,3,6--trioxy- 1D-myo-Inositol 1,4,5-trisphosph...)
Affinity DataKi:  1.65E+4nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046074(1D-2,3,6--trideoxy- 1D-myo-Inositol 1,4,5-trisphos...)
Affinity DataKi:  8.14E+4nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (S substrate)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046070((1R,2R,4R)-Cyclohexane-1,2,4-tris (methlyenephosph...)
Affinity DataKi:  1.44E+5nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (R metabolically resistant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046073(Benzene-1,2,4-tris (methylenephosphonate))
Affinity DataKi:  1.48E+5nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (R metabolically resistant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50046072((1R,2R,4R)-Cyclohexane-1,2,4-tris (methylenephosph...)
Affinity DataKi:  5.35E+5nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (R metabolically resistant)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInositol polyphosphate-5-phosphatase A(Homo sapiens (Human))
Mayo Foundation

Curated by ChEMBL
LigandPNGBDBM50407004(CHEMBL2092922)
Affinity DataKi: >1.00E+8nMAssay Description:Tested for inhibition of 5-phosphatase isolated from human erythrocyte membrane (R metabolically resistant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188657((R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20531(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Affinity DataIC50:  0.300nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241325(CHEMBL251348 | N-(4-(2-(1-isobutyl-1,2,3,6-tetrahy...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20554(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Affinity DataIC50:  0.570nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20531(N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}qui...)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225031(CHEMBL251565 | tert-butyl 4-(4-(2-acetamidobenzo[d...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188711((R)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluoromet...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.620nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20554(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Affinity DataIC50:  0.640nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188674((R)-(6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-t...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.760nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20554(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188650((R,S)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluorom...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20554(3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin...)
Affinity DataIC50:  0.900nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188717((R)-(5-chloro-6-(4-(4-(dibenzylamino)-6-(trifluoro...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188650((R,S)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluorom...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20557(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)
Affinity DataIC50:  0.900nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188682((R,S)-1-(6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188689((R)-tert-butyl 2-(4-(3-Chloro-5-(hydroxymethyl)pyr...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241322(CHEMBL398411 | N-(4-(2-morpholino-6-(4-(trifluorom...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158665((E)-3-(4-tert-Butyl-phenyl)-N-quinolin-7-yl-acryla...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225032(CHEMBL249731 | N-(4-(2-(pyridin-4-yl)-6-(4-(triflu...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188661((R)-N-(2-(4-(3-chloro-5-(hydroxymethyl)pyridin-2-y...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity against acid-induced 45calcium ion uptake in CHO cells expressing rat TRPV1 at pH5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM20556(4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}ox...)
Affinity DataIC50:  1.20nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158658((E)-3-(2-Morpholin-4-yl-6-trifluoromethyl-pyridin-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188721((R)-2-(4-(3-chloro-5-vinylpyridin-2-yl)-2-methylpi...)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225033(CHEMBL249983 | N-(4-(2-methyl-6-(4-(trifluoromethy...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188674((R)-(6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-t...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188682((R,S)-1-(6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225027(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225038(CHEMBL250185 | N-(4-(2-(piperidin-1-yl)-6-(4-(trif...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50188661((R)-N-(2-(4-(3-chloro-5-(hydroxymethyl)pyridin-2-y...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity against capsaicin-induced 45calcium ion uptake in CHO cells expressing rat TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Amgen

Curated by ChEMBL
LigandPNGBDBM50225027(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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