Affinity DataKi: 0.300nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
Affinity DataKi: 0.960nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human Glyoxalase-1More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
Affinity DataKi: 62nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
TargetHydroxyacylglutathione hydrolase, mitochondrial(Bos taurus)
Chengdu University
Curated by ChEMBL
Chengdu University
Curated by ChEMBL
Affinity DataKi: 81nMAssay Description:Inhibition of bovine liver glyoxalase 2More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 83nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 87nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 99nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
TargetHydroxyacylglutathione hydrolase, mitochondrial(Bos taurus)
Chengdu University
Curated by ChEMBL
Chengdu University
Curated by ChEMBL
Affinity DataKi: 138nMAssay Description:Inhibition of bovine liver glyoxalase 2More data for this Ligand-Target Pair
Affinity DataKi: 142nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Competitive inhibition of recombinant mouse His-tagged Glyoxalase-1 using GSH and MGO as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 151nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 151nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 155nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) using GSH and MGO as substrates preincubated with substrates for 6 mins followed by enzyme addition by sp...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKi: 194nMAssay Description:Displacement of [3H]MPEP from rat cortex mGluR5More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 229nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Competitive inhibition of recombinant mouse His-tagged Glyoxalase-1 using GSH and MGO as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 234nMAssay Description:Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...More data for this Ligand-Target Pair
Affinity DataKi: 261nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plotMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 347nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 350nMAssay Description:Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysisMore data for this Ligand-Target Pair