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Found 3544 with Last Name = 'arla' and Initial = 'r'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598740(CHEMBL5175227)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598739(CHEMBL5188215)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598738(CHEMBL5204065)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50538045(CHEMBL4636163)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062051(1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-3-[4-(2-me...)
Affinity DataKi:  0.150nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50538008(CHEMBL4638732)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062066(3-[4-(2-Methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-b...)
Affinity DataKi:  0.190nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598737(CHEMBL5205631)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50538046(CHEMBL4647198)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50538047(CHEMBL4647019)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598741(CHEMBL5204894)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50318633(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Affinity DataKi:  0.230nMAssay Description:Inhibitory concentration against Herpes simplex virus type 1 thymidine kinase(HSV-1 TK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50290872((-)-rel-3-((4aR,12aS)-2-methyl-1,2,3,4,4a,5,12,12a...)
Affinity DataKi:  0.230nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598725(CHEMBL5185397)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598743(CHEMBL5178223)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598745(CHEMBL5198823)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598734(CHEMBL5197480)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistamine H3 receptor(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50483134(CHEBI:64156 | Imetit)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3]-RAMH from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50538027(CHEMBL4644169)
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in CHOK1 cell membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598736(CHEMBL5208095)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50048485((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Affinity DataKi:  0.400nMAssay Description:The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50048485((S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]...)
Affinity DataKi:  0.400nMAssay Description:The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598744(CHEMBL5190323)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50450528(CHEMBL2051964)
Affinity DataKi:  0.460nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066647(CHEMBL113724 | {(S)-3-Methyl-1-[3-oxo-1-(4-phenoxy...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062069(4-Methoxy-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-y...)
Affinity DataKi:  0.510nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037121(2-[(1R,3S,4S)-1-BENZYL-4-[N-(BENZYLOXYCARBONYL)-L-...)
Affinity DataKi:  0.600nMAssay Description:Apparent inhibition constant against recombinant HIV-1 proteaseMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062101(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Affinity DataKi:  0.630nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062056(1-Dimethylcarbamoyl-3-{2-[4-(2-methyl-imidazo[4,5-...)
Affinity DataKi:  0.630nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062061(1-(3,3-Dimethyl-2-oxo-butyl)-3-[4-(2-methyl-imidaz...)
Affinity DataKi:  0.670nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50037124((R)-2-{(R)-2-[(S)-4-((S)-2-Benzyloxycarbonylamino-...)
Affinity DataKi:  0.700nMAssay Description:Apparent inhibition constant against recombinant HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598732(CHEMBL5192284)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408519(CHEMBL115357)
Affinity DataKi:  0.700nMAssay Description:Relative binding affinity was measured for Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062045(6-Benzofuran-2-yl-1-dimethylcarbamoyl-3-[4-(2-meth...)
Affinity DataKi:  0.780nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50408522(CHEMBL126820)
Affinity DataKi:  0.800nMAssay Description:Relative binding affinity was measured for Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062082(4-Methyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl...)
Affinity DataKi:  0.820nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataKi:  0.830nMAssay Description:Antagonist activity at 5-HT6 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062113(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Affinity DataKi:  0.850nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062064(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Affinity DataKi:  0.860nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062092((4,7-Dimethyl-1H-indol-3-yl)-[4-(2-methyl-imidazo[...)
Affinity DataKi:  0.870nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062106(4-Chloro-3-[4-(2-methyl-imidazo[4,5-b]pyridin-1-yl...)
Affinity DataKi:  0.900nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062118(4-Ethyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylm...)
Affinity DataKi:  0.910nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062048(1-Dimethylcarbamoyl-3-[4-(2-methyl-benzoimidazol-1...)
Affinity DataKi:  0.920nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50061061((4aR,8aS)-6-Ethyl-8a-(3-hydroxy-phenyl)-3-methyl-4...)
Affinity DataKi:  0.950nMAssay Description:inhibition of [3H]DADLE binding to delta-opioid receptor of mouse brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062098(1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]p...)
Affinity DataKi:  0.950nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50517508(CHEMBL4594107)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3]-RAMH from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50062054(4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]py...)
Affinity DataKi:  1nMAssay Description:Binding potency against Platelet activating factor (PAF) receptor using [3H]-C18-PAF as radioligand on rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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