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Found 749 with Last Name = 'cao' and Initial = 'd'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453725(CHEMBL5284183)
Affinity DataKi:  5.60nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50093374(2-(4-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxyli...)
Affinity DataKi:  6nMAssay Description:Inhibition of human full length PARP1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM27119(2-(1-propylpiperidin-4-yl)-1H-1,3-benzodiazole-4-c...)
Affinity DataKi:  8nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50165486(1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataKi:  12nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFatty acid-binding protein, adipocyte(Rattus norvegicus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50212873(((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPH...)
Affinity DataKi:  29nMAssay Description:Inhibition of rat ap2 by fluorescent 1,8-anilino-8-naphthalene sulfonate assayMore data for this Ligand-Target Pair
TargetFatty acid-binding protein, adipocyte(Rattus norvegicus)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50381857(CHEMBL2023268)
Affinity DataKi:  33nMAssay Description:Inhibition of rat ap2 by fluorescent 1,8-anilino-8-naphthalene sulfonate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50610277(CHEMBL5270722)
Affinity DataKi:  1.77E+3nMAssay Description:Mixed type inhibition of human BuChE assessed as inhibition constant using butyrylthiocholine iodide as substrate by lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609320(CHEMBL5272699)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609337(CHEMBL5270700)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50453726(CHEMBL3919533)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609315(CHEMBL5274219)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50517268(CHEMBL4475144)
Affinity DataIC50:  1nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50517275(CHEMBL4469040)
Affinity DataIC50:  1nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC1 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609333(CHEMBL5291238)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609339(CHEMBL5271782)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM209857(US9273052, 19 | US9566277, 19)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PARP1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609307(CHEMBL5288947)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human KGA preincubated for 15 to 30 mins followed by substrate addition and measured after 3 to 4 hrs by GDH-EZMTT reagent-based GDH co...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609313(CHEMBL5283756)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609334(CHEMBL5287824)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609318(CHEMBL5271800)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50536936(CHEMBL4584534)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609300(CHEMBL5266562)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609306(CHEMBL5289496)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609322(CHEMBL5284876)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM440444(US10633389, Example 109-3 | US20230279020, Example...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of FLAG-tagged CARM1 (unknown origin) (2 to 585 residues) using biotin-aminohexanoate-PRKQLATKAARMeKSAP-amide peptide as substrate preincu...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609319(CHEMBL5289683)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT4 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant HDAC10 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC6 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT8 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1(Homo sapiens)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT1 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3(Homo sapiens)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT3 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT6 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609332(CHEMBL5268692)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530517(CHEMBL4550548 | US11078188, Example 16)
Affinity DataIC50:  4.20nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530517(CHEMBL4550548 | US11078188, Example 16)
Affinity DataIC50:  4.20nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609317(CHEMBL5274541)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))TBA
LigandPNGBDBM50609324(CHEMBL5277620)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of human CARM1 (140 to 480 residues) incubated for 15 mins measured after 60 min by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530516(CHEMBL4587000 | US11078188, Example 9)
Affinity DataIC50:  4.5nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530516(CHEMBL4587000 | US11078188, Example 9)
Affinity DataIC50:  4.5nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530513(CHEMBL4583525 | US11078188, Example 14)
Affinity DataIC50:  4.60nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530502(CHEMBL4449874 | US11078188, Example 19)
Affinity DataIC50:  4.60nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50530513(CHEMBL4583525 | US11078188, Example 14)
Affinity DataIC50:  4.60nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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