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Found 1290 with Last Name = 'delbeck' and Initial = 'm'
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM642921(US20240000767, Example 100 | US20240000767, Exampl...)
Affinity DataKi:  2nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086170((4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-di...)
Affinity DataKi:  2nMAssay Description:Inhibition of human A2B adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415448(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoimida...)
Affinity DataKi:  2.40nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415450(3-Isopropyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoi...)
Affinity DataKi:  2.70nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415451(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxo-2,3-...)
Affinity DataKi:  2.80nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415449(3-Ethyl-5-methyl-1-(oxetan-2-ylmethyl)-6-[(2-oxoim...)
Affinity DataKi:  5.20nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415452(3-Ethyl-5-methyl-6-[(5-oxo-4,5-dihydro-1H-1,2,4-tr...)
Affinity DataKi:  6.40nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM415453(3-Ethyl-5-methyl-6-[(5-oxo-1,5-dihydro-4H-1,2,4-tr...)
Affinity DataKi:  12nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM642917(N-[(3,5-Difluoropyridin-2-yl)methyl]-2-[(3R)-3-met...)
Affinity DataKi:  24nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50336977(CHEMBL1672627 | N-[5-(3-Fluoropyridin-4-yl)-6-pyri...)
Affinity DataKi:  24nMAssay Description:Inhibition of human A2B adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415451(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxo-2,3-...)
Affinity DataKi:  100nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415448(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoimida...)
Affinity DataKi:  120nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415450(3-Isopropyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoi...)
Affinity DataKi:  270nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415449(3-Ethyl-5-methyl-1-(oxetan-2-ylmethyl)-6-[(2-oxoim...)
Affinity DataKi:  280nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415448(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoimida...)
Affinity DataKi:  330nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415453(3-Ethyl-5-methyl-6-[(5-oxo-1,5-dihydro-4H-1,2,4-tr...)
Affinity DataKi:  330nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415451(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxo-2,3-...)
Affinity DataKi:  590nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415453(3-Ethyl-5-methyl-6-[(5-oxo-1,5-dihydro-4H-1,2,4-tr...)
Affinity DataKi:  790nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415449(3-Ethyl-5-methyl-1-(oxetan-2-ylmethyl)-6-[(2-oxoim...)
Affinity DataKi:  950nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM50531422(CHEMBL4522981)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cell membranes after 120 mins by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM50531422(CHEMBL4522981)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO cell membranes after 60 mins by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415450(3-Isopropyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoi...)
Affinity DataKi:  1.10E+3nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415452(3-Ethyl-5-methyl-6-[(5-oxo-4,5-dihydro-1H-1,2,4-tr...)
Affinity DataKi:  1.50E+3nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415452(3-Ethyl-5-methyl-6-[(5-oxo-4,5-dihydro-1H-1,2,4-tr...)
Affinity DataKi:  1.70E+3nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415453(3-Ethyl-5-methyl-6-[(5-oxo-1,5-dihydro-4H-1,2,4-tr...)
Affinity DataKi:  3.30E+3nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415449(3-Ethyl-5-methyl-1-(oxetan-2-ylmethyl)-6-[(2-oxoim...)
Affinity DataKi:  6.80E+3nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM10849(1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of human A2B adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM50531422(CHEMBL4522981)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]AB-MECA from human A3 adenosine receptor expressed in HEK293 cell membranes after 120 mins by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415448(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoimida...)
Affinity DataKi:  1.10E+4nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415451(3-Ethyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxo-2,3-...)
Affinity DataKi:  1.40E+4nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM415450(3-Isopropyl-1-(2-methoxyethyl)-5-methyl-6-[(2-oxoi...)
Affinity DataKi:  1.60E+5nMAssay Description:The binding properties of the test compounds on adenosine receptors were determined in binding studies with radioligands. For this purpose, membrane ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50574215(CHEMBL4878875 | US20240000767, Example 102)
Affinity DataIC50:  0.0850nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM50574218(CHEMBL4875484 | US20240000767, Example 135)
Affinity DataIC50:  0.260nMAssay Description:In Vitro Radioligand Binding Studies for Determination of the Dissociation Constants K1 at the Human Adrenoreceptor ADRA2C (Eurofins Panlabs Discover...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM104826(US8569314, 56)
Affinity DataIC50: <0.300nMAssay Description:In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189921(US9174997, 141)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189908(US9174997, 128)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189900(US9174997, 120)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189896(US9174997, 116)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189883(US9174997, 103)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189876(US9174997, 96)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189871(US9174997, 91)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189865(US9174997, 85)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189860(US9174997, 80)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189835(US9174997, 55)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189831(US9174997, 51)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189823(US9174997, 43 (Diastereomer 1))
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189822(US9174997, 41)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189821(US9174997, 36)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189820(US9174997, 33)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM189819(US9174997, 32)
Affinity DataIC50: <0.300nMpH: 7.4 T: 2°CAssay Description:The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept...More data for this Ligand-Target Pair
In DepthDetails US Patent
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