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Target
Adenosine receptor A1
Ligand
BDBM415452
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
1500±n/a nM
Citation
 Härter, M; Kosemund, D; Delbeck, M; Kalthof, B; Wasnaire, P; Süβmeier, F; Lustig, K Heterocyclylmethyl-thienouracile as antagonists of the adenosine-A2B-receptor US Patent  US10428083 Publication Date 10/1/2019 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM415452
Synonyms:
3-Ethyl-5-methyl-6-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)methyl]-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione | US10428083, Example 113
Type:
Small organic molecule
Emp. Form.:
C15H16F3N5O3S
Mol. Mass.:
403.379
SMILES:
CCn1c(=O)n(CCC(F)(F)F)c2sc(Cn3nc[nH]c3=O)c(C)c2c1=O
Structure:
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