Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM415449
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
280±n/a nM
Citation
 Härter, M; Kosemund, D; Delbeck, M; Kalthof, B; Wasnaire, P; Süβmeier, F; Lustig, K Heterocyclylmethyl-thienouracile as antagonists of the adenosine-A2B-receptor US Patent  US10428083 Publication Date 10/1/2019 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM415449
Synonyms:
3-Ethyl-5-methyl-1-(oxetan-2-ylmethyl)-6-[(2-oxoimidazolidin-1-yl)methyl]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (Enantiomer 1) | US10428083, Example 66
Type:
Small organic molecule
Emp. Form.:
C17H22N4O4S
Mol. Mass.:
378.446
SMILES:
CCn1c(=O)n(CC2CCO2)c2sc(CN3CCNC3=O)c(C)c2c1=O
Structure:
Search PDB for entries with ligand similarity: