TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 3nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 4nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 5nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 6nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 8nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 9nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 11nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 11nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 14nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 17nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 18nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 25nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 30nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 31nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 32nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 32nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 32nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 33nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 39nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Estimated IC50 values are as follows (obtained using STANDARD KINASEPROFILER).More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 47nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 50nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 66nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 78nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 88nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 96nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 112nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 119nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 124nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 136nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 166nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 220nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 290nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 355nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 441nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Genase Therapeutics
US Patent
Genase Therapeutics
US Patent
Affinity DataIC50: 459nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
Affinity DataIC50: 570nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair