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Found 262 with Last Name = 'fernandes' and Initial = 'e'
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557298(CHEMBL4750927)
Affinity DataKi:  30nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557293(CHEMBL4781637)
Affinity DataKi:  40nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557299(CHEMBL4799812)
Affinity DataKi:  170nMAssay Description:Binding affinity to syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557299(CHEMBL4799812)
Affinity DataKi:  190nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557296(CHEMBL4792861)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557297(CHEMBL4747962)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557295(CHEMBL4758599)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557294(CHEMBL4749490)
Affinity DataKi:  250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.8kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50611873(CHEMBL5274020)
Affinity DataKi:  1.40E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223989(A-395N (6))
Affinity DataKi:  1.83E+3nM ΔG°:  -32.7kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557286(CHEMBL4798461)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557287(CHEMBL4752622)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50611878(CHEMBL5273304)
Affinity DataKi:  2.80E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611869(CHEMBL5268563)
Affinity DataKi:  7.30E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611871(CHEMBL5271556)
Affinity DataKi:  8.10E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611877(CHEMBL5287666)
Affinity DataKi:  8.50E+3nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557288(CHEMBL4792781)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50611876(CHEMBL5275750)
Affinity DataKi:  1.23E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611870(CHEMBL5289397)
Affinity DataKi:  1.48E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataKi:  1.80E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50325677(4,8-dihydroxy-7-methoxy-6-(3-methylbut-2-enyl)-2-(...)
Affinity DataKi:  1.81E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  1.94E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611881(CHEMBL5273562)
Affinity DataKi:  2.30E+4nMAssay Description:Mixed-type inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNPG as substrate incubated for 30 mins by Lineweaver-Burk double-reciproca...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557289(CHEMBL4740875)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557290(CHEMBL4798840)
Affinity DataKi:  4.40E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataKi:  8.45E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445690(CHEMBL457821)
Affinity DataKi:  9.54E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557291(CHEMBL4785814)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50312650(5,4'-dihydroxyflavone | 5-hydroxy-2-(4-hydroxyphen...)
Affinity DataKi:  1.03E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataKi:  1.07E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557292(CHEMBL4779632)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  1.22E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  1.78E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSyntenin-1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50557285(CHEMBL4788058)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50155446(1,3,7-Trihydroxy xanthone (3) | 1,3,7-Trihydroxy-x...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataIC50:  7.51nMpH: 7.5 T: 2°CAssay Description:For the assay, compounds or nonbiotinylated H3(23-34) peptide were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611917(CHEMBL2436928)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611920(CHEMBL4100829)
Affinity DataIC50:  13nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50611919(CHEMBL5274472)
Affinity DataIC50:  13nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataIC50:  18nMT: 2°CAssay Description:IC50 values were determined for compounds A-395 and A-395N at 75 nM of EZH2 trimeric complex (EZH2-EED-SUZ12), 3 μM of human nucleosome and 1 &#...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50611832(CHEMBL4856778)
Affinity DataIC50:  23nMAssay Description:Inhibition of yeast alpha-glucosidase using sucrose as substrate preincubated for 5 mins followed by sucrose addition and measured after 30 mins by s...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50485132(CHEBI:67553 | CHEMBL484030)
Affinity DataIC50:  28nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50268290(1,7-Dihydroxyxanthone | CHEBI:4946 | CHEMBL389166)
Affinity DataIC50:  36nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50611923(CHEMBL4083803)
Affinity DataIC50:  49nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as release of p-nitrophenol using pNPG as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM23406((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Affinity DataIC50:  54nMAssay Description:Inhibition of yeast alpha-glucosidase using sucrose as substrate preincubated for 5 mins followed by sucrose addition and measured after 30 mins by s...More data for this Ligand-Target Pair
In DepthDetails PubMed
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