Affinity DataKi: 0.00100nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Inhibition of recombinant JAK3Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nM ΔG°: -49.4kJ/molepH: 8.0 T: 2°CAssay Description:Assays were performed for the Itk enzyme containing residues 357-620, and an Itk enzyme containing the catalytic kinase domain and the TH and SH2 dom...More data for this Ligand-Target Pair
Affinity DataKi: <10nM ΔG°: <-45.7kJ/molepH: 8.0 T: 2°CAssay Description:Assays were performed for the Itk enzyme containing residues 357-620, and an Itk enzyme containing the catalytic kinase domain and the TH and SH2 dom...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of ALKChecked by AuthorMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 190nMAssay Description:Inhibition of cKitChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 260nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 340nMAssay Description:Inhibition of GCKChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of GMCSF-induced STAT5 phosphorylation by flow cytometryChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of JAK3 in human HT2 cells assessed as inhibition of IL2-induced STAT5 phosphorylation by flow cytometryChecked by AuthorMore data for this Ligand-Target Pair