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Found 161 with Last Name = 'frydrych' and Initial = 'cs'
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285708(US10077289, Compound 16 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  0.720nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  1.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285706(US10077289, Compound 14 | [(2S,3R,4R)-7-(5-Fluoro-...)
Affinity DataKi:  1.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285715(US10077289, Compound 23 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  2.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285710(US10077289, Compound 18 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  2.20nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285701(US10077289, Compound 9 | [(2S,3R,4R)-1-(1H-Benzimi...)
Affinity DataKi:  2.30nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285707(US10077289, Compound 15 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  2.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285725(US10077289, Compound 33 | [2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  3.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285726(US10077289, Compound 34 | [2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  3.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285714(US10077289, Compound 22 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.20nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285713(US10077289, Compound 21 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.20nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285705(US10077289, Compound 13 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.20nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285716(US10077289, Compound 24 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285704(US10077289, Compound 12 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.80nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285717(US10077289, Compound 25 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.80nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285720(US10077289, Compound 28 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.90nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285709(US10077289, Compound 17 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  3.90nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285697(US10077289, Compound 5 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  4.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285727(US10077289, Compound 35 | [2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  4.40nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285693(US10077289, Compound 2 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  4.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285695(US10077289, Compound 4 | [(2S,3R,4R)-5-(1-(N,N-Dim...)
Affinity DataKi:  5.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285698(US10077289, Compound 6 | [(2S,3R,4R)-3-Hydroxy-5-(...)
Affinity DataKi:  5.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285711(US10077289, Compound 19 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  5.40nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285729(US10077289, Compound 37 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  5.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285699(US10077289, Compound 7 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  5.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285703(US10077289, Compound 11 | [(2S,3R,4S)-3-Hydroxy-4-...)
Affinity DataKi:  5.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285712(US10077289, Compound 20 | [(2S,3R,4R)-3-Hydroxy-7-...)
Affinity DataKi:  5.70nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285719(US10077289, Compound 27 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  6.80nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285702(US10077289, Compound 10 | [(2S,3R,4R)-1-(1H-Benzim...)
Affinity DataKi:  7.10nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285700(US10077289, Compound 8 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  7.40nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285728(US10077289, Compound 36 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  7.70nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285724(US10077289, Compound 32 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  8.30nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285694(US10077289, Compound 3 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  8.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285723(US10077289, Compound 31 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  9.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285721(US10077289, Compound 29 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  11nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285718(US10077289, Compound 26 | [(2S,3R,4R)-3-Hydroxy-7-...)
Affinity DataKi:  12.2nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285722(US10077289, Compound 30 | [(2S,3R,4R)-3-Hydroxy-4-...)
Affinity DataKi:  14nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM285692(US10077289, Compound 1 | [(2S,3R,4R)-3-Hydroxy-4-m...)
Affinity DataKi:  15nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine--tRNA ligase(Staphylococcus aureus)
Gsk

LigandPNGBDBM18131(SB-243545 | butyl (2S)-2-[(2S)-2-amino-3-(4-hydrox...)
Affinity DataIC50:  0.200nMpH: 7.9 T: 2°CAssay Description:The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ...More data for this Ligand-Target Pair
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM18128((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against Bacterial Tyrosyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine--tRNA ligase(Staphylococcus aureus)
Gsk

LigandPNGBDBM18128((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)
Affinity DataIC50:  1nMpH: 7.9 T: 2°CAssay Description:The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ...More data for this Ligand-Target Pair
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222701(CHEMBL158051)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222699(CHEMBL161300)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222700(CHEMBL161864)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222703(CHEMBL160841)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222702(CHEMBL161347)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222705(CHEMBL161312)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine--tRNA ligase(Staphylococcus aureus)
Gsk

LigandPNGBDBM18130((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...)
Affinity DataIC50:  3nMpH: 7.9 T: 2°CAssay Description:The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ...More data for this Ligand-Target Pair
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124821(2-[3-(3,5-Dichloro-benzylamino)-propylamino]-1H-qu...)
Affinity DataIC50:  3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222704(CHEMBL345835)
Affinity DataIC50: <3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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