TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.00230nM ΔG°: -69.1kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.00400nM ΔG°: -66.1kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.00550nM ΔG°: -66.9kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.00680nM ΔG°: -66.3kJ/molepH: 6.2 T: 2°CAssay Description:Inhibition constants were determined by a fluorometric assay with the fluorogenic substrate Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Lys(DABCYL)-Ar...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.0110nM ΔG°: -63.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.0120nM ΔG°: -63.4kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.0300nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0700nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0700nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.0700nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0700nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.112nM ΔG°: -57.7kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.200nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.210nM ΔG°: -57.5kJ/molepH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.260nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.270nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.310nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.310nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.390nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.390nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.410nM ΔG°: -55.7kJ/mole IC50: 2.20nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.410nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.470nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
National Cancer Institute-Bethesda
National Cancer Institute-Bethesda
Affinity DataKi: 0.530nM ΔG°: -55.1kJ/mole IC50: 1.80nMpH: 6.2 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.530nMAssay Description:Tested for binding affinity against HIV proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Aids Drug Screening And Development Laboratory
Curated by ChEMBL
Affinity DataKi: 0.620nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair