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Found 649 with Last Name = 'ihnat' and Initial = 'ma'
TargetAminopeptidase N(Homo sapiens (Human))
The University Of Oklahoma Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50435737(PROBESTIN)
Affinity DataKi:  19nMAssay Description:Inhibition of aminopeptidase N (unknown origin) using L-leucine-beta-naphthylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232828(CHEMBL4099329)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232823(CHEMBL4099682)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50552403(CHEMBL4800264)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232827(CHEMBL4104515)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051308((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...)
Affinity DataIC50:  6nMAssay Description:Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232823(CHEMBL4099682)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50001839(CHEMBL428647 | PACLITAXEL | taxol)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232828(CHEMBL4099329)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50552402(CHEMBL3040513)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50552407(CHEMBL4758455)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50:  10nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50019928(CHEMBL3287222)
Affinity DataIC50:  21nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat hippocampal Gamma-aminobutyric acid type B receptor (weak agonist)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232828(CHEMBL4099329)
Affinity DataIC50:  27nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232823(CHEMBL4099682)
Affinity DataIC50:  27nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50019931(CHEMBL3287219)
Affinity DataIC50:  30nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232827(CHEMBL4104515)
Affinity DataIC50:  30nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232824(CHEMBL4060996)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Toxoplasma gondii DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232827(CHEMBL4104515)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232826(CHEMBL4069672)
Affinity DataIC50:  34nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232826(CHEMBL4069672)
Affinity DataIC50:  39nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50019930(CHEMBL3287220)
Affinity DataIC50:  41nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50552406(CHEMBL4763551)
Affinity DataIC50:  43nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232825(CHEMBL4072383)
Affinity DataIC50:  47nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50019929(CHEMBL3287221)
Affinity DataIC50:  50nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  83nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232825(CHEMBL4072383)
Affinity DataIC50:  84nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232826(CHEMBL4069672)
Affinity DataIC50:  90nMAssay Description:Inhibition of PDGFR-beta in human SF539 cells assessed as reduction in PDGF-BB induced phosphorylation preincubated for 60 mins followed by PDGF-BB a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM4811((Z)-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-y...)
Affinity DataIC50:  100nMAssay Description:Inhibition of PDGF-stimulated PDGFRbeta phosphorylation expressed in mouse NIH/3T3 cells by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50360178(CHEMBL1929556)
Affinity DataIC50:  100nMAssay Description:Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318173(CHEMBL1095762 | N4-(4-Bromo-2-chlorophenyl)-6-(2,4...)
Affinity DataIC50:  100nMAssay Description:Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rattus norvegicus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235696(CHEMBL4060383)
Affinity DataIC50:  120nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Rattus norvegicus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50235700(CHEMBL4096329)
Affinity DataIC50:  140nMAssay Description:Inhibition of human thymidylate synthase using dUMP/(6R,S)-tetrahydrofolate as substrate/co-factor by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50430573(CHEMBL2337373)
Affinity DataIC50:  147nMAssay Description:Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50232822(CHEMBL4098409)
Affinity DataIC50:  167nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF induced phosphorylation preincubated for 60 mins followed by EGF addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50552404(CHEMBL4751710)
Affinity DataIC50:  180nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50019927(CHEMBL3287223)
Affinity DataIC50:  182nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50318174(CHEMBL1095761 | N4-(3-bromophenyl)-6-(2,4-dichloro...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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