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Found 572 with Last Name = 'isaac' and Initial = 'mb'
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098549((6aR,aR)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116963(2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116967(2-[2-(6-Bromo-indol-1-yl)-ethyl]-decahydro-pyrido[...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116960(2-[2-(6-Trifluoromethyl-indol-1-yl)-ethyl]-decahyd...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116971(6-Bromo-1-[2-(4-cyclopropylmethyl-[1,4]diazepan-1-...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116951(2-[2-(6-Chloro-indol-1-yl)-ethyl]-decahydro-pyrido...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116970(6-Bromo-1-[2-(4-cyclopentyl-[1,4]diazepan-1-yl)-et...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116943(6-Bromo-1-[2-(4-isopropyl-[1,4]diazepan-1-yl)-ethy...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116964(6-Bromo-1-[2-(4-cyclopropyl-[1,4]diazepan-1-yl)-et...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116944(6-Bromo-1-[2-(4-cyclohexyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116966(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-triflu...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116958(6-Bromo-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  31nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098550(3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116965(6-Chloro-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116950(6-Bromo-1-[2-(4-isobutyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  37nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116956(6-Isopropenyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-e...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116952(2-[2-(6-Bromo-indol-1-yl)-ethyl]-octahydro-pyrido[...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116955(5-Bromo-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  88nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116962(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-thioph...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116948(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-vinyl-...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116945(6-Methyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  125nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116959(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-nitro-...)
Affinity DataKi:  139nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116947(6-Ethynyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116949(6-Isopropyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  145nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116968(2-[2-(5-Bromo-indol-1-yl)-ethyl]-octahydro-pyrido[...)
Affinity DataKi:  158nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116961(6-Bromo-1-{2-[4-(2,2-dimethyl-propyl)-[1,4]diazepa...)
Affinity DataKi:  163nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116946(6-Ethyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  166nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116954(6-Benzyloxy-1-[2-(4-methyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  182nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116953(6-Fluoro-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  288nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116957(6-Methoxy-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]-LSDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116967(2-[2-(6-Bromo-indol-1-yl)-ethyl]-decahydro-pyrido[...)
Affinity DataKi:  4.07E+3nMAssay Description:Compound wastested for its binding affinity towards 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <2nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544399(CHEMBL4638273)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528209(CHEMBL4526828)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50: <3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528196(CHEMBL4575655)
Affinity DataIC50:  3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566950(CHEMBL4852125)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant full-length human GRK6 using casein as substrate measured after 80 mins in presence of [gamma33P]ATP by radiometric scintil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50566949(CHEMBL4877302)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human GRK6 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544408(CHEMBL4641207)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528195(CHEMBL4435320)
Affinity DataIC50:  4nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528208(CHEMBL4440168)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50544414(CHEMBL4641530)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528188(CHEMBL4553210)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528203(CHEMBL4434694)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50528204(CHEMBL4565968)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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